CYP2C19基因多态性及其对质子泵抑制剂疗效影响研究进展

被引:23
作者
李小雯
郑松柏
机构
[1] 复旦大学附属华东医院消化科
关键词
质子泵抑制剂; 细胞色素c类; 基因型; 基因多态性; 研究;
D O I
暂无
中图分类号
R975 [消化系统药物];
学科分类号
摘要
质子泵抑制剂(PPI)是目前临床上治疗酸相关性疾病的首选药物。但其疗效存在个体差异,且其对老年人和肝肾功能不全患者的安全性也倍受关注。这些问题都与患者CYP2C19基因多态性有密切关系。本文对CYP2C19基因多态性及其对PPI的药动学、药效学和临床疗效的影响作一综述,并对临床合理应用PPI作进一步探讨。
引用
收藏
页码:775 / 779
页数:5
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