表皮生长因子受体-酪氨酸激酶抑制剂的耐药机制及其应对策略

被引:3
作者
张雪艳
韩宝惠
机构
[1] 上海交通大学附属胸科医院呼吸内科
关键词
D O I
暂无
中图分类号
R734.2 [肺肿瘤];
学科分类号
100117 [系统生物医学];
摘要
表皮生长因子受体-酪氨酸激酶抑制剂(EGFR-TKI)的耐药机制仍在探索中,了解耐药机制有助于在治疗前筛选可能的敏感患者,同时还可以指导设计针对性的药物去对抗耐药,恢复对药物的敏感性。研究开发新型不可逆性EGFR抑制剂、新型多靶点TKI、小分子与抗体TKI的联合应用或许是解决EGFR-TKI的有效途径。
引用
收藏
页码:45 / 48+3 +3
页数:5
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