补肾中药调控BMP-Smad信号通路促进牵张成骨的研究进展

被引：16

作者：

余翔

姜自伟

郑晓辉

蔡群斌

李悦

黄枫

李康活

金志超

欧阳崇志

孙世栋

黄泽青

吕迪

莫颖杰

机构：

[1] 广州中医药大学第一临床医学院

[2] 广州中医药大学第一附属医院创伤骨科

[3] 广州中医药大学附属骨伤科医院

来源：

辽宁中医杂志 | 2017年 / 44卷 / 09期

基金：

广东省自然科学基金;

关键词：

牵张成骨; 骨形态发生蛋白; BMP-smad; 补肾法; 综述;

D O I：

10.13192/j.issn.1000-1719.2017.09.072

中图分类号：

R274 [中医骨伤科];

学科分类号：

100508 [中医骨伤科学];

摘要：

牵张成骨是骨科肢体重建的重要技术,但治疗周期长和新骨形成不佳是亟待解决的关键问题。应用外源性BMP是目前促进成骨的主要方法,但存在诸多缺陷,促进内源性BMP合成、提高生物利用度是解决问题的有效途径。补肾法促进骨形成的作用确切,对于激活BMP-smad信号通路也有巨大的潜能,但在牵张成骨中的作用靶点和调节机制尚未明确。文章就目前补肾中药调控BMP-Smad信号通路促进牵张成骨的相关研究作一综述。

引用

收藏

页码：1991 / 1994

页数：4

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