比较尼卡地平与拉贝洛尔治疗重度妊娠期高血压疾病的差异

被引：4

作者：

崔芳

徐珊

刘佳

赵文霞

机构：

[1] 上海市虹口区江湾医院妇产科

来源：

黑龙江医药科学 | 2017年 / 40卷 / 05期

关键词：

尼卡地平; 拉贝洛尔; 妊娠期高血压疾病;

D O I：

暂无

中图分类号：

R714.246 [];

学科分类号：

100211 ;

摘要：

目的:评估尼卡地平治疗重度妊娠期高血压疾病的可行性。方法:根据纳入及排除标准随机分为尼卡地平组(21例)与拉贝洛尔组(24例),两组静脉滴注尼卡地平或拉贝洛尔注射液,并根据血压随时调节药量直至目标血压(140～150/90～100mm Hg,比较两组药物血压、心率变化、药物不良反应、孕妇心脏指数(CI)及外周阻力(TPR)变化以及对胎儿、妊娠结局的影响。结果:两组用药后收缩压、舒张压及平均动脉压均出现明显下降,用药前后比较差异显著(P<0.01);尼卡地平组用药后心率增快,拉贝洛尔组用药后心率减缓,无需特殊处理;两组药物起效时间(4.42±1.38 vs 5.91±1.45)、血压达标时间(12.33±5.24 vs15.64±7.02)及有效率(95.24%vs 95.83%)比较差异无显著性(P>0.05);两组均未出现明显不良反应;心脏超声多普拉检测用药前后孕妇心脏指数及外周阻力均得到明显改善(P<0.05、P<0.01);两组胎儿用药前后脐血流S/D值变化及胎心率变化无差异(P>0.05);两组各发生产后出血1例,无心衰、肺水肿、子痫及孕产妇死亡发生(P>0.05);两组分娩孕周<34周与≥34周中,新生儿出生体重、新生儿重度窒息及围产儿死亡比较无差别(P>0.05)。结论:尼卡地平在重度妊娠期高血压疾病的紧急降压治疗中其安全性、有效性与拉贝洛尔相当,可作为拉贝洛尔禁忌症患者的替代药物。

引用

页码：40 / 42

页数：3

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