乙型肝炎病毒相关肝硬化的临床诊断、评估和抗病毒治疗的综合管理

被引：12

作者：

科技部十二五重大专项联合课题组专家

茅益民 ^{[1
]}

尤红 ^{[2
]}

贾继东 ^{[2
]}

机构：

[1] 上海交通大学医学院附属仁济医院

[2] 首都医科大学附属北京友谊医院

来源：

肝脏 | 2014年 / 19卷 / 01期

关键词：

肝硬化; 抗病毒治疗; 失代偿期; 临床诊断;

D O I：

10.14000/j.cnki.issn.1008-1704.2014.01.022

中图分类号：

R575.2 [肝硬变];

学科分类号：

1002 ; 100201 ;

摘要：

<正>一、背景慢性乙型肝炎病毒(HBV)感染是肝硬化的重要原因。研究显示,有效抑制HBV复制可改善肝纤维化[1-2],延缓或阻止代偿期肝硬化向失代偿期的进展,防止失代偿期患者病情进一步恶化,减少门静脉高压及相关并发症发生[3-6],延长生存期[3-4]。因此,有效的抗病毒治疗对改善疾病临床结局具有重要意义[7],也是目前HBV相关肝硬化整体治疗策略中的一个重要组成部分。近年来,我国、亚太地区、欧洲和美国肝病学会更新的慢性乙型肝炎诊治指南或共识,都明确指出应该给予HBV相关肝硬化患者积极、有效的抗病毒治疗。然而目前各国指南或共识中提出的抗病毒治疗意见比较简单,难以完全满足临床实践的需求。为此,我们组织国内有关专家,系统总结

引用

页码：42 / 52

页数：11

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