EGR转录因子在肿瘤中的研究进展

被引：17

作者：

孙小霞

张颖

辛晓燕

机构：

[1] 第四军医大学西京医院妇产科

来源：

现代肿瘤医学 | 2017年 / 25卷 / 04期

关键词：

EGR; 肿瘤; 增殖; 分化; 侵袭; 凋亡;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 [肿瘤学];

摘要：

早期生长反应基因(early growthresponse,EGR)家族包括EGR1、EGR2、EGR3、EGR4 4个成员,能够被多种细胞外的信号分子激活,在细胞内产生级联放大作用。其特点是都包含有一个高度保守的可以与DNA结合的结构域,该结构域由3个相同的锌指结构(Cys2His2)组成,能够特异性识别并与其下游调控基因的启动子区5'-GCGGGGGCG-3'序列结合,发挥转录调控作用。作为EGR家族的重要成员,EGR1在肿瘤的相关研究中较多,可参与肿瘤细胞的增殖、分化、凋亡及侵袭转移等过程。而EGR2、EGR3和EGR4在肿瘤中的研究较少。

引用

页码：654 / 657

页数：4

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