毒死蜱的神经毒性作用及机制

被引：16

作者：

王会平

伍一军

机构：

[1] 中国科学院动物学研究所分子毒理学实验室农业虫害鼠害综合治理研究国家重点实验室

来源：

环境与职业医学 | 2008年 / 03期

关键词：

毒死蜱; 神经毒性; 作用机制;

D O I：

10.13213/j.cnki.jeom.2008.03.010

中图分类号：

R114 [卫生毒理];

学科分类号：

100405 ;

摘要：

毒死蜱是目前世界上生产和销售量最大的有机磷杀虫剂之一,广泛应用于农作物病虫害和家庭卫生害虫防治之中,其对环境中生物的毒性尤其是对人类健康的影响一直是毒理学研究热点。本综述就毒死蜱的最主要毒性——神经毒性及其毒性作用机制的研究进展作一详细报道。

引用

页码：314 / 318

页数：5

共 10 条

[1]

Comparative developmental neurotoxicity of organophosphates in vivo: Transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems[J] . Theodore A. Slotkin,Frederic J. Seidler.Brain Research Bulletin . 2007 (4)

[2] Chlorpyrifos induces apoptosis in human monocyte cell line U937 [J].

Nakadai, Ari ;

Li, Qing ;

Kawada, Tomoyuki .

TOXICOLOGY, 2006, 224 (03) :202-209

[3] Dermal absorption of chlorpyrifos in human volunteers [J].

Meuling, WJA ;

Ravensberg, LC ;

Roza, L ;

van Hemmen, JJ .

INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, 2005, 78 (01) :44-50

[4]

Selective Effects of Insecticides on Nigrostriatal Dopaminergic Nerve Pathways[J] . Jeffrey R. Bloomquist,Rebecca L. Barlow,Jeffrey S. Gillette,Wen Li,Michael L. Kirby.Neurotoxicology . 2002 (4)

[5]

Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells[J] . S.J. Garcia,F.J. Seidler,T.L. Crumpton,T.A. Slotkin.Brain Research . 2001 (1)

[6]

The toxicity of chlorpyrifos towards differentiating mouse N2a neuroblastoma cells[J] . M Sachana,J Flaskos,E Alexaki,P Glynn,A.J Hargreaves.Toxicology in Vitro . 2001 (4)

[7]

Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: effects on nuclear transcription factors involved in cell replication and differentiation[J] . T.L Crumpton,F.J Seidler,T.A Slotkin.Brain Research . 2000 (1)

[8] Is oxidative stress involved in the developmental neurotoxicity of chlorpyrifos? [J].

Crumpton, TL ;

Seidler, FJ ;

Slotkin, TA .

DEVELOPMENTAL BRAIN RESEARCH, 2000, 121 (02) :189-195

[9]

The legislation of toxicologic safety factors: the food quality protection act with chlorpyrifos as a test case[J] . James L Schardein,Anthony R Scialli.Reproductive Toxicology . 1999 (1)

[10]

In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides[J] . D. Bagchi,M. Bagchi,E.A. Hassoun,S.J. Stohs.Toxicology . 1995 (1)

← 1 →