5-HT1A受体对抑郁焦虑行为的调节作用及其机制

被引：44

作者：

苏晖 ^{[1
,2
]}

施慎逊 ^{[2
]}

机构：

[1] 上海交通大学医学院附属精神卫生中心

[2] 复旦大学附属华山医院精神医学科

来源：

上海交通大学学报(医学版) | 2015年 / 35卷 / 09期

关键词：

5-HT1A受体; 抑郁; 焦虑; 调节;

D O I：

暂无

中图分类号：

R749.4 [情感性精神病];

学科分类号：

100204 [神经病学];

摘要：

5-羟色胺(5-HT)水平异常引起的神经递质-受体信号通路的适应性改变涉及大脑功能紊乱和神经精神疾病产生,与抑郁症、焦虑症的发病机制密切相关。5-HT1A受体是脑内分布最广的5-HT受体亚型,已是临床抑郁焦虑障碍药物治疗的重要靶点。本文从电生理学、转基因动物学、信号通路、药理学角度综述5-HT1A受体对抑郁焦虑的调节作用及其机制,有助于深入理解5-HT1A受体功效。

引用

页码：1403 / 1406

页数：4

共 13 条

[1]

Upregulation of the dorsal raphe nucleus-prefrontal cortex serotonin system by chronic treatment with escitalopram in hyposerotonergic Wistar-Kyoto rats.[J].Makiko Yamada;Yukie Kawahara;Fumi Kaneko;Yuki Kishikawa;Naoki Sotogaku;Wilfred J. Poppinga;Joost H.A. Folgering;Eliyahu Dremencov;Hiroshi Kawahara;Akinori Nishi.Neuropharmacology.2013,

[2]

Serotonin 5-HT1A Receptors as Targets for Agents to Treat Psychiatric Disorders: Rationale and Current Status of Research [J].

Celada, Pau ;

Bortolozzi, Analia ;

Artigas, Francesc .

CNS DRUGS, 2013, 27 (09) :703-716

[3]

Serotonin 1A auto-receptors are not sufficient to modulate anxiety in mice [J].

Piszczek, Lukasz ;

Schlax, Kevin ;

Wyrzykowska, Anna ;

Piszczek, Agnieszka ;

Audero, Enrica ;

Gross, Cornelius Thilo .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2013, 38 (04) :2621-2627

[4]

Acute 5-HT1A autoreceptor knockdown increases antidepressant responses and serotonin release in stressful conditions [J].

Ferres-Coy, Albert ;

Santana, Noemi ;

Castane, Anna ;

Cortes, Roser ;

Carmona, Maria C. ;

Toth, Miklos ;

Montefeltro, Andres ;

Artigas, Francesc ;

Bortolozzi, Anala .

PSYCHOPHARMACOLOGY, 2013, 225 (01) :61-74

[5]

5-HT1A Receptor Agonists Enhance Pyramidal Cell Firing in Prefrontal Cortex Through a Preferential Action on GABA Interneurons [J].

Llado-Pelfort, Laia ;

Santana, Noemi ;

Ghisi, Valentina ;

Artigas, Francesc ;

Celada, Pau .

CEREBRAL CORTEX, 2012, 22 (07) :1487-1497

[6]

5-HT 1A ; 5-HT 2A ; and 5-HT 2C receptor mRNA modulation by antidepressant treatment in the chronic mild stress model of depression: sex differences exposed.[J].P.M. Pitychoutis;C. Dalla;A.C. Sideris;P.A. Tsonis;Z. Papadopoulou-Daifoti.Neuroscience.2012,

[7]

Different actions for acute and chronic administration of mirtazapine on serotonergic transmission associated with raphe nuclei and their innervation cortical regions [J].

Yamamura, Satoshi ;

Abe, Masao ;

Nakagawa, Masanori ;

Ochi, Shinichiro ;

Ueno, Shu-ichi ;

Okada, Motohiro .

NEUROPHARMACOLOGY, 2011, 60 (04) :550-560

[8]

Preferential in vivo action of F15599; a novel 5‐HT<sub>1A</sub> receptor agonist; at postsynaptic 5‐HT<sub>1A</sub> receptors.[J].LLladó‐Pelfort;M‐BAssié;ANewman‐Tancredi;FArtigas;PCelada.British Journal of Pharmacology.2010, 8

[9]

5-HT1A receptor-regulated signal transduction pathways in brain [J].