延迟性化疗相关性恶心呕吐的治疗进展

被引：28

作者：

王盈

林英城

机构：

[1] 汕头大学医学院附属肿瘤医院内科

来源：

临床肿瘤学杂志 | 2014年 / 19卷 / 10期

关键词：

化疗相关性恶心呕吐; 延迟性; 治疗;

D O I：

暂无

中图分类号：

R730.53 [化学（药物）疗法];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

化疗相关性恶心呕吐(CINV)严重影响肿瘤患者的生活质量。随着止呕药物的发展,急性、延迟性CINV的控制率较前已有明显升高,但延迟性CINV的控制率仍偏低。第1代5-羟色胺3(5-HT3)受体拮抗剂对延迟性CINV的控制率并不优于单用地塞米松、甲氧氯普胺和丙氯拉嗪。最近研究表明第2代5-HT3受体拮抗剂帕洛诺司琼、神经激肽1受体拮抗剂在控制延迟性CINV方面上优于第1代5-HT3受体拮抗剂,当其联合抗精神病药物如奥氮平、丙氯拉嗪等可明显提高延迟性CINV的控制率。本文对延迟性化疗相关性恶心呕吐的治疗进展作一综述。

引用

页码：945 / 949

页数：5

共 13 条

[1]

Pooled analysis of phase III clinical studies of palonosetron versus ondansetron, dolasetron, and granisetron in the prevention of chemotherapy-induced nausea and vomiting (CINV) [J].

Schwartzberg, Lee ;

Barbour, Sally Y. ;

Morrow, Gary R. ;

Ballinari, Gianluca ;

Thorn, Michael D. ;

Cox, David .

SUPPORTIVE CARE IN CANCER, 2014, 22 (02) :469-477

[2]

The use of olanzapine versus metoclopramide for the treatment of breakthrough chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy [J].

Navari, Rudolph M. ;

Nagy, Cindy K. ;

Gray, Sarah E. .

SUPPORTIVE CARE IN CANCER, 2013, 21 (06) :1655-1663

[3]

Management of Chemotherapy-Induced Nausea and Vomiting.[J].Rudolph M. Navari.Drugs.2013, 3

[4]

Palonosetron plus single-dose dexamethasone for the prevention of nausea and vomiting in women receiving anthracycline/cyclophosphamide-containing chemotherapy: meta-analysis of individual patient data examining the effect of age on outcome in two phase III trials [J].

Celio, Luigi ;

Bonizzoni, Erminio ;

Bajetta, Emilio ;

Sebastiani, Silvia ;

Perrone, Tania ;

Aapro, Matti S. .

SUPPORTIVE CARE IN CANCER, 2013, 21 (02) :565-573

[5]

Prevention of Delayed Nausea: A University of Rochester Cancer Center Community Clinical Oncology Program Study of Patients Receiving Chemotherapy [J].

Roscoe, Joseph A. ;

Heckler, Charles E. ;

Morrow, Gary R. ;

Mohile, Supriya G. ;

Dakhil, Shaker R. ;

Wade, James L. ;

Kuebler, J. Philip .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (27) :3389-3395

[6]

Effect of Ginger on Acute and Delayed Chemotherapy-Induced Nausea and Vomiting.[J].Yunes Panahi;Alireza Saadat;Amirhossein Sahebkar;Farshad Hashemian;Mojgan Taghikhani;Ehsan Abolhasani.Integrative Cancer Therapies.2012, 3

[7]

Randomized, double-blinded, placebo-controlled trial of ondansetron plus dexamethasone with or without metoclopramide as antiemetic prophylaxis in patients receiving high-dose cisplatin in medical practice [J].

Ithimakin, Suthinee ;

Runglodvatana, Kanakorn ;

Nimmannit, Akarin ;

Akewanlop, Charuwan ;

Srimuninnimit, Vichien ;

Keerativitayanan, Narong ;

Soparattanapaisarn, Nopadol ;

Laocharoenkeat, Apirom .

SUPPORTIVE CARE IN CANCER, 2012, 20 (04) :849-855

[8]

A phase III open-label study to assess safety and efficacy of palonosetron for preventing chemotherapy-induced nausea and vomiting (CINV) in repeated cycles of emetogenic chemotherapy [J].

Aogi, Kenjiro ;

Sakai, Hiroshi ;

Yoshizawa, Hirohisa ;

Masuda, Norikazu ;

Katakami, Nobuyuki ;

Yanagita, Yasuhiro ;

Inoue, Kenichi ;

Kuranami, Masaru ;

Mizutani, Mitsuhiro ;

Masuda, Noriyuki .

SUPPORTIVE CARE IN CANCER, 2012, 20 (07) :1507-1514

[9]

Treatment of chemotherapy-induced nausea.[J].Rudolph M. Navari.Community Oncology.2012, 1

[10]

Olanzapine Versus Aprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting: A Randomized Phase III Trial.[J].Rudolph M. Navari;Sarah E. Gray;Andrew C. Kerr.The Journal of Supportive Oncology.2011, 5

← 1 2 →