脑源性神经营养因子在孤独症谱系障碍发病机制中的作用

被引：5

作者：

郑臻

屈艺

母得志

机构：

[1] 成都,四川大学华西第二医院儿科,出生缺陷与相关妇儿疾病教育部重点实验室

来源：

中华实用儿科临床杂志 | 2016年 / 31卷 / 24期

关键词：

脑源性神经营养因子; 孤独症谱系障碍; 发病机制;

D O I：

暂无

中图分类号：

R749.94 [儿童精神病];

学科分类号：

100204 [神经病学];

摘要：

脑源性神经营养因子(BDNF)在神经系统中的发育和功能中起重要作用。BDNF通过多种途径调控神经元的生存、分化、树突和轴突生长、突触形成、神经元可塑性、学习和记忆的基本过程, BDNF的调控功能失调可能是BDNF参与孤独症谱系障碍发病的重要机制。现就BDNF与孤独症谱系障碍作一综述。

引用

共 27 条

[11]

Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid [J].

Nicolini, Chiara ;

Ahn, Younghee ;

Michalski, Bernadeta ;

Rho, Jong M. ;

Fahnestock, Margaret .

ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2015, 3 :3

[12]

An experimental rat model of sporadic Alzheimer's disease and rescue of cognitive impairment with a neurotrophic peptide [J].

Bolognin, Silvia ;

Blanchard, Julie ;

Wang, Xiaochuan ;

Basurto-Islas, Gustavo ;

Tung, Yunn Chyn ;

Kohlbrenner, Erik ;

Grundke-Iqbal, Inge ;

Iqbal, Khalid .

ACTA NEUROPATHOLOGICA, 2012, 123 (01) :133-151

[13]

Increased BDNF levels and NTRK2 gene association suggest a disruption of BDNF/TrkB signaling in autism [J].

Correia, C. T. ;

Coutinho, A. M. ;

Sequeira, A. F. ;

Sousa, I. G. ;

Venda, L. Lourenco ;

Almeida, J. P. ;

Abreu, R. L. ;

Lobo, C. ;

Miguel, T. S. ;

Conroy, J. ;

Cochrane, L. ;

Gallagher, L. ;

Gill, M. ;

Ennis, S. ;

Oliveira, G. G. ;

Vicente, A. M. .

GENES BRAIN AND BEHAVIOR, 2010, 9 (07) :841-848

[14]

BDNF-Akt-Bcl2 Antiapoptotic Signaling Pathway Is Compromised in the Brain of Autistic Subjects [J].

Sheikh, Ashfaq M. ;

Malik, Mazhar ;

Wen, Guang ;

Chauhan, Abha ;

Chauhan, Ved ;

Gong, Cheng-Xin ;

Liu, Fei ;

Brown, William T. ;

Li, Xiaohong .

JOURNAL OF NEUROSCIENCE RESEARCH, 2010, 88 (12) :2641-2647

[15]

Blood BDNF concentrations reflect brain-tissue BDNF levels across species.[J].Anders B. Klein;Rebecca Williamson;Martin A. Santini;Christoffer Clemmensen;Anders Ettrup;Maribel Rios;Gitte M. Knudsen;Susana Aznar.The International Journal of Neuropsychopharmacology.2010, 3

[16]

Postsynaptic BDNF-TrkB Signaling in Synapse Maturation, Plasticity, and Disease [J].

Yoshii, Akira ;

Constantine-Paton, Martha .

DEVELOPMENTAL NEUROBIOLOGY, 2010, 70 (05) :304-322

[17]

Katoh-Semba, Ritsuko ;

Wakako, Rie ;

Komori, Taku ;

Shigemi, Hiroko ;

Miyazaki, Noriko ;

Ito, Hironori ;

Kumagai, Toshiyuki ;

Tsuzuki, Masako ;

Shigemi, Kenji ;

Yoshida, Futoshi ;

Nakayama, Atsuo .

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 2007, 25 (06) :367-372

[18]

Epigenetic mechanisms underlying the role of brain-derived neurotrophic factor in depression and response to antidepressants [J].

Duclot, Florian ;

Kabbaj, Mohamed .

JOURNAL OF EXPERIMENTAL BIOLOGY, 2015, 218 (01) :21-31

[19]

Serum Brain-derived neurotrophic factor levels in Chinese children with autism spectrum disorders: a pilot study..[J].Zhang Qing-biao;Jiang Liang-fu;Kong Ling-yu;Lu Yuan-Jun.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.2014, 1

[20]

Brain-Derived Neurotrophic Factor in children with Autism Spectrum Disorder [J].

Kasarpalkar, Nikhil J. ;

Kothari, Sweta T. ;

Dave, Usha P. .

ANNALS OF NEUROSCIENCES, 2014, 21 (04) :129-133

← 1 2 3 →