MTRR基因A66G多态性与儿童急性淋巴细胞白血病关系的Meta分析

被引：6

作者：

马利敏 ^{[1
]}

阮林海 ^{[1
]}

刘洪超 ^{[2
]}

冯艳铭 ^{[2
]}

杨海平 ^{[1
]}

机构：

[1] 河南科技大学第一附属医院血液科

[2] 河南科技大学医学院

来源：

肿瘤防治研究 | 2015年 / 42卷 / 08期

关键词：

甲硫氨酸合成酶还原酶; 基因多态性; 急性淋巴细胞白血病; 风险; Meta分析;

D O I：

暂无

中图分类号：

R733.71 [急性白血病];

学科分类号：

100214 [肿瘤学];

摘要：

目的评估甲硫氨酸合成酶还原酶(MTRR)基因A66G多态性与儿童急性淋巴细胞白血病(ALL)发生风险的关系。方法全面检索Pub Med、Elsevier、Embase、中文期刊全文数据库(CNKI)和万方数据库,收集探索MTRR基因A66G多态性与儿童ALL发生关系的病例对照研究,纳入符合入选标准的文献并评估其质量。优势比(ORs)及95%可信区间(CIs)评估关联强度。应用Rev Man 5.2软件对纳入研究进行异质性检验和效应值合并,漏斗图评估发表性偏倚,敏感性分析采用逐一排除的方法以评估结果的稳定性。结果共纳入7篇文献,包括儿童ALL患者2 326例,对照3 090例。异质性检验结果表明纳入研究间无显著异质性,采用固定效应模型合并数据。Meta分析结果示,在整体人群纯合子模型和显性模型发现MTRR A66G多态性与儿童ALL风险有关联(GG vs.AA:OR=0.81,95%CI:0.69～0.95,P=0.009;AG+GG vs.AA:OR=0.87,95%CI:0.77～0.98,P=0.03);根据种族进行亚组分析时在白种人群中发现显著性关联(AG vs.AA:OR=0.84,95%CI:0.72～0.99,P=0.04;GG vs.AA:OR=0.79,95%CI:0.66～0.95,P=0.01;AG+GG vs.AA:OR=0.82,95%CI:0.71～0.96,P=0.01)。漏斗图未检测出显著性发表性偏倚,敏感性分析表明结果稳定可靠。结论目前Meta分析表明MTRR基因A66G多态性与儿童ALL发生风险存在关联,尤其在白种人群。

引用

页码：824 / 828

页数：5

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