IL-17、IL-6对DSS诱导的小鼠慢性结肠炎结肠癌模型的调控作用的初步研究

被引：12

作者：

陈思铭

成浩

张芸

赵强

吴震州

赵立青

机构：

[1] 南开大学生命科学学院

来源：

南开大学学报(自然科学版) | 2015年 / 01期

基金：

天津市自然科学基金;

关键词：

IL-17; IL-6; 溃疡性结肠炎; 慢性结肠癌; IFN-γ;

D O I：

暂无

中图分类号：

R735.35 [];

学科分类号：

摘要：

IL-17是Th17细胞产生的诱导炎症反应的早期启动因子,IL-6是活化的T细胞和成纤维细胞产生的一种多效的促炎性细胞因子,都参与溃疡性结肠炎结肠癌的发生发展过程.通过DSS诱导小鼠慢性结肠癌模型,利用IL-17及IL-6基因敲除小鼠,分析了IL-17、IL-6在肠癌模型中对肿瘤的形成,对机体免疫反应过程中主要T细胞亚型及细胞因子的影响.结果显示,敲除IL-17能加重慢性肠炎诱导的结肠癌.这种加剧作用并不是通过影响T细胞的激活,而是可能通过上调CD8+T细胞的IFN-γ加重慢性肠炎进而促进肠癌的发生.敲除IL-6对肠癌表型影响不显著,但对T细胞的功能的影响与IL-17类似.该工作为深入探讨IL-17、IL-6对慢性结肠癌发生的调控机制奠定了一定的基础.

引用

页码：7 / 13

页数：7

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