木犀草素抗肝细胞癌作用及机制的研究进展

被引：29

作者：

杨培伟

张树辉

机构：

[1] 上海中医药大学附属岳阳中西医结合医院病理科

来源：

中药药理与临床 | 2018年 / 34卷 / 01期

关键词：

木犀草素; 肝细胞癌; 作用; 机制; 研究进展;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

100806 [中药药理学];

摘要：

目的:探讨木犀草素抗肝细胞癌的作用及机制研究进展情况。方法:回顾性分析近几年来国内外对木犀草素抗肝细胞癌的相关文献,对目前木犀草素抗肝细胞癌的作用及机制研究进展做一综述。结果:木犀草素抑制肝细胞癌的生长、浸润和转移,对肝细胞癌有增效、增敏、减毒、抗氧化和抗突变的作用;可以通过多机制、多途径、多靶点抗肝细胞癌。结论:有必要进一步探讨木犀草素抗肝细胞癌的作用及机制,为木犀草素抗肝细胞癌的临床应用和基因靶向等新药开发奠定一定的理论基础和科学依据。

引用

页码：190 / 193

页数：4

共 17 条

[1]

半枝莲总黄酮中7种成分的含量测定及抗肿瘤活性 [J].

田新宇 ;

范翠梅 ;

渠田田 ;

朱恩圆 ;

季莉莉 ;

侴桂新 .

中国实验方剂学杂志, 2017, 23 (01) :53-59

[2]

基于木犀草素联合阿霉素治疗肝癌基础研究 [J].

王锦秀 ;

黎涛 ;

赵平 .

实用医院临床杂志, 2016, 13 (06) :25-28

[3]

Modulatory effect of luteolin on redox homeostasis and inflammatory cytokines in a mouse model of liver cancer [J].

Zhang, Qiang ;

Yang, Jie ;

Wang, Jun .

ONCOLOGY LETTERS, 2016, 12 (06) :4767-4772

[4]

Connexin 32 and luteolin play protective roles in non-alcoholic steatohepatitis development and its related hepatocarcinogenesis in rats [J].

Sagawa, Hiroyuki ;

Naiki-Ito, Aya ;

Kato, Hiroyuki ;

Naiki, Taku ;

Yamashita, Yoriko ;

Suzuki, Shugo ;

Sato, Shinya ;

Shiomi, Kosuke ;

Kato, Akihisa ;

Kuno, Toshiya ;

Matsuo, Yoichi ;

Kimura, Masahiro ;

Takeyama, Hiromitsu ;

Takahashi, Satoru .

CARCINOGENESIS, 2015, 36 (12) :1539-1549

[5]

Luteolin Induces Apoptosis by Up-regulating miR-34a in Human Gastric Cancer Cells [J].

Wu, Hao ;

Huang, Min ;

Liu, Yatian ;

Shu, Yongqian ;

Liu, Ping .

TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2015, 14 (06) :747-755

[6]

Luteolin synergizes the antitumor effects of 5-fluorouracil against human hepatocellular carcinoma cells through apoptosis induction and metabolism.[J].Huanli Xu;Tao Yang;Xiaohui Liu;Ye Tian;Xiaoliang Chen;Ru Yuan;Shuonan Su;Xiukun Lin;Guanhua Du.Life Sciences.2016, 1

[7]

Growth inhibition of luteolin on HepG2 cells is induced via p53 and Fas/Fas-ligand besides the TGF-β pathway [J].

Yee, Su Bog ;

Choi, Hye Joung ;

Chung, Sang Woon ;

Park, Dong Heun ;

Sung, Bokyung ;

Chung, Hae Young ;

Kim, Nam Deuk .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2015, 47 (02) :747-754

[8]

Anti-hepatoma cells function of luteolin through inducing apoptosis and cell cycle arrest [J].

Ding, Shixiong ;

Hu, Airong ;

Hu, Yaoren ;

Ma, Jianbo ;

Weng, Pengjian ;

Dai, Jinhua .

TUMOR BIOLOGY, 2014, 35 (04) :3053-3060

[9]

Luteolin sensitizes the antiproliferative effect of interferon α/β by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 in cancer cells [J].

Tai, Zhengfu ;

Lin, Yuan ;

He, Yujiao ;

Huang, Junmei ;

Guo, Jiajia ;

Yang, Lijuan ;

Zhang, Guolin ;

Wang, Fei .

CELLULAR SIGNALLING, 2014, 26 (03) :619-628

[10]

Evaluation of the antioxidant and anti-inflammatory nature of luteolin in experimentally induced hepatocellular carcinoma.[J].K. Balamurugan;J. Karthikeyan.Biomedicine & Preventive Nutrition.2012, 2

← 1 2 →