β淀粉样蛋白的神经毒性作用及治疗研究进展

被引：4

作者：

向诗琪

陈萍

机构：

[1] 重庆医科大学附属第一医院麻醉科

来源：

世界科技研究与发展 | 2012年 / 34卷 / 06期

关键词：

β-淀粉样蛋白; 神经毒性; 药物治疗;

D O I：

10.16507/j.issn.1006-6055.2012.06.034

中图分类号：

R749.16 [];

学科分类号：

100203 ;

摘要：

β-淀粉样蛋白(beta-amyloid protein,Aβ)的产生和清除失衡,导致其在脑内异常聚集,是引发神经退行性疾病如阿尔兹海默病(alzheimer's disease,AD)的关键因素之一。目前研究还发现,全身麻醉药也可以通过增加脑组织中Aβ的表达,引起认知功能障碍。本文将对Aβ的产生、Aβ损害神经功能的具体机制及治疗Aβ神经毒性药物的最新研究进展进行综述。

引用

页码：993 / 995

页数：3

共 26 条

[1]

Beta-amyloid: a disease target or a synaptic regulator affecting age-related neurotransmitter changes?. E Mura,C Lanni,S Preda. Current Pharmaceutical Design . 2010

[2]

Curcumin mediates presenilin-1 activity to reduce P-amyloid production in a model of Alzheimer’’s Disease. Xiong Z,Hongmei Z,Lu S,Yu L. Pharmacol Rep . 2011

[3]

Prolonged Aβtreatment leads to impairment in the ability of primary cortical neurons to maintain K-+ andCa- (2+) homeostasis. Shabala L,Howells C,West AK, et al. Mol Neurodegener . 2010

[4]

Amyloid precursor protein trafficking, processing,and function. THINAKARAN G,KOO E H. Journal of Biological Chemistry . 2008

[5]

Curcumin Promotes Abeta Fibrillation and Reduces Neurotoxicity in Transgenic Drosophila. CAESAR I,JONSON M,NILSSON K P,et al. PLoS One . 2012

[6] Nitrous Oxide Plus Isoflurane Induces Apoptosis and Increases β-Amyloid Protein Levels [J].

Zhen, Yu ;

Dong, Yuanlin ;

Wu, Xu ;

Xu, Zhipeng ;

Lu, Yan ;

Zhang, Yiying ;

Norton, David ;

Tian, Ming ;

Li, Shuren ;

Xie, Zhongcong .

ANESTHESIOLOGY, 2009, 111 (04) :741-752

[7] Aβ42 production in brain capillary endothelial cells after oxygen and glucose deprivation [J].

Bulbarelli, Alessandra ;

Lonati, Elena ;

Brambilla, Anna ;

Orlando, Antonina ;

Cazzaniga, Emanuela ;

Piazza, Fabrizio ;

Ferrarese, Carlo ;

Masserini, Massimo ;

Sancini, Giulio .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2012, 49 (04) :415-422

[8] Pattern Recognition Receptors and Inflammation [J].

Takeuchi, Osamu ;

Akira, Shizuo .

CELL, 2010, 140 (06) :805-820

[9]

Anesthetic Sevoflurane Causes Neurotoxicity Differently in Neonatal Na?ve and Alzheimer Disease Transgenic Mice[J] . Yan Lu,Xu Wu,Yuanlin Dong,Zhipeng Xu,Yiying Zhang,Zhongcong Xie. &nbspAnesthesiology . 2010 (6)

[10]

Formation of the 42-mer Amyloid B Radical and the Therapeutic Role of Superoxide Dismutase in Alzheimer’’s Disease. MURAKAMI K,SHIMIZU T,IRIE K. Journal of Amino Acids . 2011

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