血脑屏障上的P-糖蛋白及其转运功能研究进展

被引：8

作者：

姬汴生

机构：

[1] 河南大学药学院药理教研室

来源：

河南大学学报(医学版) | 2008年 / 01期

关键词：

P-糖蛋白; 血脑屏障; 转运动能;

D O I：

10.15991/j.cnki.41-1361/r.2008.01.025

中图分类号：

R96 [药理学];

学科分类号：

100706 [药理学];

摘要：

P-糖蛋白(P-glycoprotein,P-gp)是一个由分子量170-180KD组成的糖蛋白,其主动的药物外排作用是造成肿瘤细胞产生多药耐药性(Multidrug resistance,MDR)的重要原因。近年来研究发现,P-糖蛋白在机体正常组织如血脑屏障(blood-brain barrier,BBB)也呈高度表达。本文归纳了P-糖蛋白的逆转剂及其底物的特征,系统介绍了血脑屏障上P-糖蛋白的转运功能及其研究方法,期望为P-糖蛋白逆转剂的应用以及中枢神经系统疾病的治疗提供帮助。

引用

页码：8 / 13

页数：6

共 10 条

[1]

A co-culture-based model of human blood–brain barrier: application to active transport of indinavir and in vivo–in vitro correlation.[J]..Brain Research.2002, 2

[2]

Multidrug-resistance mdr1a/1b double knockout mice are more sensitive than wild type mice to acute arsenic toxicity; with higher arsenic accumulation in tissues.[J].Jie Liu;Yaping Liu;Douglas A Powell;Michael P Waalkes;Curtis D Klaassen.Toxicology.2002, 1

[3]

Establishment and functional characterization of an in vitro model of the blood–brain barrier; comprising a co-culture of brain capillary endothelial cells and astrocytes.[J].Pieter Jaap Gaillard;Levina Helena Voorwinden;Jette Lyngholm Nielsen;Alexei Ivanov;Ryo Atsumi;Helena Engman;Carina Ringbom;Albertus Gerrit de Boer;Douwe Durk Breimer.European Journal of Pharmaceutical Sciences.2001, 3

[4]

Affinity for the P-glycoprotein efflux pump at the blood-brain barrier may explain the lack of CNS side-effects of modern antihistamines [J].

Chishty, M ;

Reichel, A ;

Siva, J ;

Abbott, NJ ;

Begley, DJ .

JOURNAL OF DRUG TARGETING, 2001, 9 (03) :223-228

[5]

Cholesterol interaction with the daunorubicin binding site of P-glycoprotein [J].

Wang, EJ ;

Casciano, CN ;

Clement, RP ;

Johnson, WW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 276 (03) :909-916

[6]

Induction of blood–brain barrier properties in immortalized bovine brain endothelial cells by astrocytic factors.[J].Kazuya Sobue;Naoki Yamamoto;Kazuhiro Yoneda;Mark E Hodgson;Kyoko Yamashiro;Nobuo Tsuruoka;Takako Tsuda;Hirotada Katsuya;Yutaka Miura;Kiyofumi Asai;Taiji Kato.Neuroscience Research.1999, 2

[7]

Effect of the P-glycoprotein inhibitor, SDZ PSC 833, on the blood and brain pharmacokinetics of colchicine [J].