帕金森病焦虑的发病机制及研究进展

被引:21
作者
房进平
冯涛
机构
[1] 首都医科大学附属北京天坛医院神经内科
关键词
帕金森病; 焦虑; 发病率; 抗焦虑药; 早期诊断;
D O I
暂无
中图分类号
R742.5 [震颤麻痹综合征]; R749.72 [];
学科分类号
摘要
<正>帕金森病是常见的神经系统疾病,我国≥65岁人群中患病率约为1.7%[1]。以往认为,帕金森病的病理生理改变主要在于黑质多巴胺神经元的缺失,进而引起皮质基底节环路功能异常,导致运动障碍的发生。静止性震颤、运动迟缓、肌强直和姿势步态异常为帕金森病的主要运动症状。但近年来,帕金森病非运动症状得到了更为广泛和深入的认识,病理生理研究发现,帕金森病病理改变可累及周围神经系统
引用
收藏
页码:774 / 776
页数:3
相关论文
共 18 条
  • [11] Dopamine Modulates the Response of the Human Amygdala: A Study in Parkinson's Disease .2 Aless,ro Tessitore,Ahmad R. Hariri,Francesco Fera,William G. Smith,Thomas N. Chase,Thomas M. Hyde,Daniel R. Weinberger,Venkata S. Matt. J. Neurosci . 2002
  • [12] Neuropsychiatric Aspects of Parkinson’s Disease[J] . Laura Marsh.Psychosomatics . 2011 (1)
  • [13] Anxiety in Parkinson’s disease: A critical review of experimental and clinical studies[J] . Rui D.S. Prediger,Filipe C. Matheus,Marcelo L. Schwarzbold,Marcelo M.S. Lima,Maria A.B.F. Vital.Neuropharmacology . 2011 (1)
  • [14] Anxious Personality Predicts an Increased Risk of Parkinson's Disease
    Bower, James H.
    Grossardt, Brandon R.
    Maraganore, Demetrius M.
    Ahlskog, J. Eric
    Colligan, Robert C.
    Geda, Yonas E.
    Therneau, Terry M.
    Rocca, Walter A.
    [J]. MOVEMENT DISORDERS, 2010, 25 (13) : 2105 - 2113
  • [15] Automatic Mood-Congruent Amygdala Responses to Masked Facial Expressions in Major Depression
    Suslow, Thomas
    Konrad, Carsten
    Kugel, Harald
    Rumstadt, Daniel
    Zwitserlood, Pienie
    Schoening, Sonja
    Ohrmann, Patricia
    Bauer, Jochen
    Pyka, Martin
    Kersting, Anette
    Arolt, Volker
    Heindel, Walter
    Dannlowski, Udo
    [J]. BIOLOGICAL PSYCHIATRY, 2010, 67 (02) : 155 - 160
  • [16] Association between depression severity and amygdala reactivity during sad face viewing in depressed preschoolers: An fMRI study[J] . Michael S. Gaffrey,Joan L. Luby,Andy C. Belden,Jonathan S. Hirshberg,Jennifer Volsch,Deanna M. Barch.Journal of Affective Disorders . 2010 (1)
  • [17] Parkinson's disease in China: prevalence in Beijing, Xian, and Shanghai[J] . Zhen-Xin Zhang,Gustavo C Roman,Zhen Hong,Cheng-Bing Wu,Qiu-Ming Qu,Jue-Bing Huang,Bing Zhou,Zhi-Ping Geng,Ji-Xing Wu,Hong-Bo Wen,Heng Zhao,Gwendolyn EP Zahner.The Lancet . 2005 (9459)
  • [18] Prospective study of phobic anxiety and risk of Parkinson's disease
    Weisskopf, MG
    Chen, HL
    Schwarzschild, MA
    Kawachi, I
    Ascherio, A
    [J]. MOVEMENT DISORDERS, 2003, 18 (06) : 646 - 651