Hyperhomocysteinemia as a potential contributor of colorectal cancer development in inflammatory bowel diseases: A review

被引：18

作者：

Ammar Hassanzadeh Keshteli ^{[1
]}

Vickie E Baracos ^{[2
]}

Karen L Madsen ^{[1
]}

机构：

[1] Department of Medicine,University of Alberta,Edmonton,Alberta T6G 2E1,Canada

[2] Department of Oncology,University of Alberta,Cross Cancer Institute,Edmonton,Alberta T6G 2E1,Canada

来源：

World Journal of Gastroenterology | 2015年 / 21卷 / 04期

关键词：

Hyperhomocysteinemia; Colorectal cancer; Inflammatory bowel disease;

D O I：

暂无

中图分类号：

R735.34 [];

学科分类号：

100214 ;

摘要：

Homocysteine is an amino acid generated metabolically by the S-adenosylmethionine-dependent transmethylation pathway. In addition to being a well-known independent risk factor for coronary heart disease, is also a risk factor for cancer. Patients suffering from inflammatory bowel diseases(IBD) including ulcerative colitis and Crohn’s disease are at increased risk of developing colorectal cancer in comparison to healthy individuals. Furthermore, the risk of hyperhomocysteinaemia is significantly higher in IBD patients when compared with controls. In the present article, we review the mechanisms in which hyperhomocysteinemia may contribute to increased risk of colorectal cancer in IBD patients.

引用

页码：1081 / 1090

页数：10