Helicobacter pylori and colorectal neoplasia:Is there a causal link?

被引:14
作者
Vasilios Papastergiou [1 ]
Stylianos Karatapanis [1 ]
Sotirios D Georgopoulos [2 ]
机构
[1] Department of Internal Medicine, General Hospital of Rhodes
[2] Department of Gastroenterology,Athens Medical, Paleo Faliron General Hospital
关键词
Helicobacter pylori; Colorectal cancer; Polyp; Adenoma; Gastrin;
D O I
暂无
中图分类号
R735.34 []; R57 [消化系及腹部疾病];
学科分类号
1002 ; 100201 ; 100214 ;
摘要
Ever since Helicobacter pylori(H. pylori) was recognized as an infectious cause of gastric cancer, there has been increasing interest in examining its potential role in colorectal carcinogenesis. Data from casecontrol and cross-sectional studies, mostly relying on hospital-based samples, and several meta-analyses have shown a positive statistical relationship between H. pylori infection and colorectal neoplasia. However, the possibility exists that the results have been influenced by bias, including the improper selection of patients and disparities with respect to potential confounders. While the evidence falls short of a definitive causal link, it appears that infection with H. pylori /H. pylori-related gastritis is associated with an increased, although modest, risk of colorectal adenoma and cancer. The pathogenic mechanisms responsible for this association remain uncertain. H. pylori has been detected in colorectal malignant tissues; however, the possibility that H. pylori is a direct activator of colonic carcinogenesis remains purely hypothetical. On the other hand, experimental data have indicated a series of potential oncogenic interactions between these bacteria and colorectal mucosa, including induction and perpetuation of inflammatory responses, alteration of gut microflora and release of toxins and/or hormonal mediators, such as gastrin, which may contribute to tumor formation.
引用
收藏
页码:649 / 658
页数:10
相关论文
共 42 条
[1]   Stem cells in gastric cancer [J].
Yue Zhao ;
Fei Feng ;
Yong-Ning Zhou .
World Journal of Gastroenterology, 2015, 21 (01) :112-123
[2]   Helicobacter pylori infection concomitant with metabolic syndrome further increase risk of colorectal adenomas [J].
Ying-Lung Lin ;
Jui-Kun Chiang ;
Shih-Min Lin ;
Chih-En Tseng .
World Journal of Gastroenterology, 2010, 16 (30) :3841-3846
[3]   Helicobacter pylori but not gastrin is associated with the development of colonic neoplasms [J].
Selgrad, Michael ;
Bornschein, Jan ;
Kandulski, Arne ;
Hille, Carla ;
Weigt, Jochen ;
Roessner, Albert ;
Wex, Thomas ;
Malfertheiner, Peter .
INTERNATIONAL JOURNAL OF CANCER, 2014, 135 (05) :1127-1131
[4]  
Yu Guo,Hai-Yan Li.Association between Helicobacter pylori infection and colorectal neoplasm risk: A meta-analysis Based on East Asian population[J].Journal of Cancer Research and Therapeutics,2014(8)
[5]   Helicobacter pylori secreted peptidyl prolyl cis, trans-isomerase drives Th17 inflammation in gastric adenocarcinoma [J].
Amedei, Amedeo ;
Munari, Fabio ;
Della Bella, Chiara ;
Niccolai, Elena ;
Benagiano, Marisa ;
Bencini, Lapo ;
Cianchi, Fabio ;
Farsi, Marco ;
Emmi, Giacomo ;
Zanotti, Giuseppe ;
de Bernard, Marina ;
Kundu, Manikuntala ;
D'Elios, Mario Milco .
INTERNAL AND EMERGENCY MEDICINE, 2014, 9 (03) :303-309
[6]   The relationship of Helicobacter pylori infection and colon neoplasia, on the basis of meta-analysis [J].
Rokkas, Theodore ;
Sechopoulos, Panos ;
Pistiolas, Dimitrios ;
Kothonas, Fotis ;
Margantinis, Georgios ;
Koukoulis, Georgios .
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2013, 25 (11) :1286-1294
[7]  
Q. Wu,Z.‐P. Yang,P. Xu,L.‐C. Gao,D.‐M. Fan.Association between H elicobacter pylori infection and the risk of colorectal neoplasia: a systematic review and meta‐analysis[J].Colorectal Dis,2013(7)
[8]  
Akiko Shiotani,Putao Cen,David Y. Graham.Eradication of gastric cancer is now both possible and practical[J].Seminars in Cancer Biology,2013
[9]  
Izumi Inoue,Jun Kato,Noriko Yoshimura,Yoshimasa Maeda,Kosaku Moribata,Naoki Shingaki,Hisanobu Deguchi,Shotaro Enomoto,Takao Maekita,Kazuki Ueda,Mikitaka Iguchi,Hideyuki Tamai,Mitsuhiro Fujishiro,Nobutake Yamamichi,Tatsuya Takeshita,Masao Ichinose.Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori‑associatedchronic atrophic gastritis: A follow‑up study of patients with endoscopicallyresected colorectal neoplasia[J].Molecular and Clinical Oncology,2013
[10]   Precancerous colorectal lesions (Review) [J].
Conteduca, Vincenza ;
Sansonno, Domenico ;
Russi, Sabino ;
Dammacco, Franco .
INTERNATIONAL JOURNAL OF ONCOLOGY, 2013, 43 (04) :973-984