Helicobacter pylori secreted peptidyl prolyl cis, trans-isomerase drives Th17 inflammation in gastric adenocarcinoma

被引：102

作者：

Amedei, Amedeo ^{[1
,2
]}

Munari, Fabio ^{[3
]}

Della Bella, Chiara ^{[1
]}

Niccolai, Elena ^{[1
]}

Benagiano, Marisa ^{[1
]}

Bencini, Lapo ^{[4
]}

Cianchi, Fabio ^{[5
]}

Farsi, Marco ^{[4
]}

Emmi, Giacomo ^{[2
]}

Zanotti, Giuseppe ^{[3
]}

de Bernard, Marina ^{[3
]}

Kundu, Manikuntala ^{[6
]}

D'Elios, Mario Milco ^{[1
,2
]}

机构：

[1] Univ Florence, Dept Internal Med, I-50134 Florence, Italy

[2] AOU Careggi Firenze, I-50134 Florence, Italy

[3] VIMM Padua, I-35129 Padua, Italy

[4] AOU Careggi, Div Gen & Oncol Surg, Florence, Italy

[5] Univ Florence, Dept Med & Surg Crit Care, I-50134 Florence, Italy

[6] Bose Inst, Dept Chem, Kolkata 700009, India

来源：

INTERNAL AND EMERGENCY MEDICINE | 2014年 / 9卷 / 03期

关键词：

Gastric cancer; Helicobacter pylori; Pathogenesis; Cytokines; Th17; VEGF; Matrix metalloproteinase; ENDOTHELIAL GROWTH-FACTOR; EPITHELIAL-CELLS; T-CELLS; IMMUNE-RESPONSES; FACTOR-BETA; PROTEIN; MUCOSA; CANCER; IL-17; ANGIOGENESIS;

D O I：

10.1007/s11739-012-0867-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Helicobacter pylori infection is characterized by an inflammatory infiltrate, consisting mainly of neutrophils and T cells. This study was undertaken to evaluate the type of gastric T cell response elicited by the secreted peptidyl prolyl cis, trans-isomerase of H. pylori (HP0175) in patients with distal gastric adenocarcinoma. The cytokine profile and the effector functions of gastric tumor-infiltrating lymphocytes (TILs) specific for HP0175 was investigated in 20 patients with distal gastric adenocarcinoma and H. pylori infection. The helper function of HP0175-specific TILs for monocyte MMP-2, MMP-9, and VEGF production was also investigated. TILs cells from H. pylori infected patients with distal gastric adenocarcinoma produced Interleukin (IL)-17 and IL-21 in response to HP0175. HP0175-specific TILs showed poor cytolytic activity while expressing helper activity for monocyte MMP-2, MMP-9 and VEGF production. These findings indicate that HP0175 is able to drive gastric Th17 response. Thus, HP0175, by promoting pro-inflammatory low cytotoxic TIL response, matrix degradation and pro-angiogenic pathways, may provide a link between H. pylori and gastric cancer.

引用

页码：303 / 309

页数：7

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