LOTUS, a potent blocker of Nogo receptor-1 causing inhibition of axonal growth

被引：1

作者：

Yuji Kurihara

Kohtaro Takei

机构：

[1] MolecularMedicalBioscienceLaboratory,DepartmentofMedicalLifeScience,YokohamaCityUniversityGraduateSchoolofMedicalLifeScience,Suehiro-cho--,Tsurumi-ward,Yokohama-,Japan

来源：

Neural Regeneration Research | 2015年 / 10卷 / 01期

关键词：

OMgp; MAG; a potent blocker of Nogo receptor-1 causing inhibition of axonal growth; LOTUS;

D O I：

暂无

中图分类号：

R338.1 [神经原生理学];

学科分类号：

0710 ; 071006 ;

摘要：

<正>Glia-derived axonal growth inhibitory proteins limit functional repair following damage to the adult central nervous system(CNS).Nogo proteins,myelin-associated glycoprotein(MAG),oligodendrocyte myelin glycoprotein(OMgp)and B lymphocyte stimulator(BLy S),are 4 inhibitors that commonly interact with the neuronal receptor,Nogo receptor-1(Ng R1),leading to inhibition of axonal growth.Here,we demonstrate that lateral olfactory tract usher substance

引用

页码：46 / 48

页数：3

共 12 条

[11]

BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. Markus Krumbholz,Diethilde Theil,Tobias Derfuss,Andreas Rosenwald,Frank Schrader,Camelia-Maria Monoranu,Susan L. Kalled,Donna M. Hess,Barbara Serafini,Francesca Aloisi,Hartmut Wekerle,Reinhard Hohlfeld,Edgar Mei. The Journal of Experimental Medicine . 2005

[12]

Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation. Steven Petratos,Ezgi Ozturk,Michael F. Azari,Rachel Kenny,Jae Young Lee,Kylie A. Magee,Alan R. Harvey,Courtney McDonald,Kasra Taghian,Leon Moussa,Pei Mun Aui,Christopher Siatskas,Sara Litwak,Michael G. Fehlings,Stephen M. Strittmatter,Claud. Brain . 2012

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