中药有效成分防治骨性关节炎的研究进展

被引：26

作者：

韩晗 ^{[1
,2
]}

张媛媛 ^{[1
,2
]}

潘立 ^{[1
,2
]}

陈正东 ^{[1
,2
]}

薛漓轩 ^{[1
,2
]}

余伯阳 ^{[1
,2
]}

寇俊萍 ^{[1
,2
]}

机构：

[1] 中国药科大学江苏省中药评价与转化重点实验室

[2] 中国药科大学中药学院

来源：

中国药科大学学报 | 2018年 / 49卷 / 03期

关键词：

中药; 骨性关节炎; 作用机制;

D O I：

暂无

中图分类号：

R274.9 [现代医学骨伤科疾病];

学科分类号：

100210 [外科学];

摘要：

骨性关节炎(osteoarthritis,OA)是临床上常见的慢性退行性关节疾病,其发病率随着年龄的增加逐渐上升,严重影响中老年患者的生活质量。现阶段对于OA的药物治疗如非甾体类抗炎药物(nonsteroidal anti-inflammatory drugs,NSAIDs)和镇痛药,虽能改善OA症状,但不能阻止OA的进展。中药有效成分在治疗OA疾病方面具有独特的优势。本文从中药有效成分抑制炎症相关因子的分泌、改善软骨基质合成及分解代谢失衡、抑制软骨细胞凋亡、促进软骨细胞增殖、调节雌激素水平等方面综述了近五年来国内外期刊报道的中药有效成分防治OA的研究进展,以期为OA的新药研发提供理论依据。

引用

页码：279 / 285

页数：7

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