依达拉奉对脂多糖诱导的大鼠多巴胺能神经元变性保护作用的研究

被引：3

作者：

徐芳 ^{[1
]}

任士卿 ^{[1
]}

王彦永 ^{[2
]}

刘俊艳 ^{[1
]}

机构：

[1] 河北医科大学第三医院神经内科

[2] 河北省脑老化与认知神经科学实验室

来源：

脑与神经疾病杂志 | 2009年 / 17卷 / 01期

关键词：

依达拉奉; 脂多糖; 小胶质细胞; 帕金森病; 大鼠;

D O I：

暂无

中图分类号：

R742.5 [震颤麻痹综合征];

学科分类号：

摘要：

目的探讨自由基清除剂依达拉奉对脂多糖(LPS)诱导的多巴胺能神经元变性的保护作用。方法18只大鼠随机分成3组:磷酸缓冲液(PBS)对照组、生理盐水+LPS组(生理盐水治疗组)和依达拉奉+LPS组(依达拉奉治疗组)。黑质内立体定向注射15μg(2μl)LPS或PBS,采用免疫组织化学方法观察注射后14d大鼠黑质酪氨酸羟化酶(TH)阳性细胞的数量以及小胶质细胞的形态学变化。结果与对照组相比,生理盐水治疗组TH阳性细胞数减少到对侧的16%(P<0.05),细胞突触也明显减少;依达拉奉治疗组TH阳性细胞数较生理盐水治疗组明显增多,为对侧的59%(P<0.05),部分突触存在。两治疗组小胶质细胞形态无明显差异。结论依达拉奉显著抑制LPS诱导的黑质多巴胺能神经元变性。

引用

页码：64 / 67

页数：4

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