NALP3炎性体在痛风发病中的作用与药物治疗研究进展

被引：16

作者：

王璐

李璐

陈光亮

机构：

[1] 安徽中医药大学中西医结合临床学院

来源：

生命科学 | 2016年 / 28卷 / 03期

关键词：

痛风; NALP3炎性体; 药物治疗;

D O I：

10.13376/j.cbls/2016050

中图分类号：

R589.7 [嘌呤（Purine）代谢障碍];

学科分类号：

100201 [内科学];

摘要：

痛风是体内嘌呤代谢紊乱引起尿酸钠盐沉积所致的晶体相关性疾病。近年研究表明,核苷酸结合寡聚化结构域样受体3(nucleotide-binding oligomerization domain-like receptor protein 3,NALP3)炎性体活化与巨噬细胞吞噬尿酸钠晶体密切相关。NALP3炎性体活化后可剪切半胱天冬酶-1并促进白介素1β释放,引起痛风炎症反应。现将从NALP3炎性体的组成及活化、尿酸钠晶体的吞噬识别途径,以及以NALP3炎性体为靶点的抗痛风药物等方面作一综述。

引用

页码：405 / 408

页数：4

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