mTOR相关信号通路介导的自噬对肝损伤的调控作用

被引：14

作者：

黄倩 ^{[1
]}

李京涛 ^{[2
]}

刘永刚 ^{[2
]}

魏海梁 ^{[3
]}

闫曙光 ^{[4
]}

郭英君 ^{[5
]}

常占杰 ^{[2
]}

机构：

[1] 陕西中医药大学第一临床医学院

[2] 陕西中医药大学附属医院肝病一科

[3] 陕西中医药大学附属医院普外一科

[4] 陕西中医药大学基础医学院

[5] 宁夏回族自治区人民医院感染疾病科

来源：

临床肝胆病杂志 | 2020年 / 36卷 / 11期

关键词：

自噬; 肝损伤; 哺乳动物雷帕霉素靶蛋白; 信号传导;

D O I：

暂无

中图分类号：

R575 [肝及胆疾病];

学科分类号：

100201 [内科学];

摘要：

自噬能调节肝脏生理、平衡肝脏代谢。自噬激活对肝损伤的作用是双面、复杂的,受多种因素调控,与多种蛋白通路相关联。总结了mTOR机制靶点在自噬调节中的作用,其通过PI3K/AKT上游信号通路相应地抑制或增强自噬水平,参与相关肝脏疾病的生理病理变化。故而综述mTOR/PI3K/AKT自噬通路在肝损伤方面的研究进展,旨在为相关肝脏疾病提供新的治疗靶点。

引用

页码：2621 / 2625

页数：5

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