PI3K/Akt信号通路在肿瘤研究中的进展

被引：76

作者：

李建 ^{[1
]}

周怀君 ^{[2
]}

机构：

[1] 东南大学医学院

[2] 南京大学附属鼓楼医院妇产科

来源：

东南大学学报(医学版) | 2014年 / 33卷 / 03期

关键词：

磷酯酰肌醇-3激酶; 蛋白激酶B; 肿瘤; 文献综述;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 [肿瘤学];

摘要：

磷酯酰肌醇-3激酶/蛋白激酶B(PI3K/Akt)信号通路是肿瘤、炎症等发生发展过程中一条重要的信号通路。研究发现,在许多肿瘤组织中,PI3K/Akt信号通路过度表达和活化与肿瘤的进展密切相关。上游分子通过与PI3K结合,使其构象发生改变,从而磷酸化激活Akt,Akt的活化能调控其下游分子,参与肿瘤调控通路。近年来,PI3K/Akt信号通路在肿瘤中的重要作用受到众多学者的关注,多种肿瘤组织中检测到PI3K/Akt信号通路的过度活化,因此靶向该信号通路的研究成为研究热点。目前关于靶向PI3K/Akt信号通路的抗肿瘤药物在肿瘤治疗方面的临床试验已经展开,Wortmannin、LY294002等PI3K/Akt信号通路抑制剂有着广阔的临床应用前景。

引用

收藏

页码：392 / 395

页数：4

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