23价肺炎球菌多糖疫苗预防社区获得性肺炎效果的Meta分析

被引：13

作者：

朱航

黄蓉娜

杨汝沛

马林

机构：

[1] 成都市疾病预防控制中心

来源：

预防医学情报杂志 | 2018年 / 34卷 / 04期

关键词：

23价肺炎球菌多糖疫苗; 社区获得性肺炎; Meta分析;

D O I：

暂无

中图分类号：

R563.1 [肺炎];

学科分类号：

100201 [内科学];

摘要：

目的分析23价肺炎球菌多糖疫苗(PPV23)预防社区获得性肺炎的效果。方法通过检索Pub Med数据库、Cochrane图书馆、EMbase数据库、CNKI、万方数据库以及维普数据库,收集PPV23预防社区获得性肺炎效果评价的随机对照试验,检索时间截至2016-08-20。通过筛选文献、提取资料及质量评价后,采用Stata 11.0软件进行Meta分析。结果本次Meta分析共纳入8个随机对照试验,合计157 177名研究对象。结果提示:(1)接种PPV23者社区获得性肺炎发病率较低(OR=0.87,95%CI:0.76～0.98,P=0.023);(2)接种PPV23者链球菌性社区获得性肺炎发病率无差异(OR=0.74,95%CI:0.31～1.77,P=0.493);(3)接种PPV23者总死亡率无差异(OR=0.67,95%CI:0.43～1.04,P=0.072);(4)接种PPV23者肺炎归因死亡率无差异(OR=1.03,95%CI:0.90～1.16,P=0.685)。结论 PPV23可在一定程度上预防社区获得性肺炎的发生,但保护效果较弱。由于偏倚因素及混杂因素影响,上述结论需更多高质量的随机对照试验加以论证。

引用

页码：422 / 426

页数：5

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