exosomes在胃癌中作用机制的研究进展

被引：4

作者：

姜惠琴

于珊

刘天舒

机构：

[1] 复旦大学附属中山医院肿瘤内科

来源：

临床肿瘤学杂志 | 2016年 / 21卷 / 01期

关键词：

exosomes; 胃癌; 进展;

D O I：

暂无

中图分类号：

R735.2 [胃肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

exosomes是一种大小为30～100 nm的囊泡状小体,能被多种细胞分泌,存在于各种体液中。exosomes作为一种全新的细胞间信息传递系统,广泛参与肿瘤的发生、发展。胃癌来源的exosomes通过运输miRNA、细胞因子等关键物质,影响靶细胞内PI3K/Akt、MAPK/ERK等信号转导通路,参与胃癌细胞增殖、侵袭、转移、免疫逃逸等过程。现就近年来exosomes在胃癌中作用机制的研究进行综述。

引用

收藏

页码：82 / 87

页数：6

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