AQP3在皮肤病发病机制中的作用研究进展

被引:23
作者
张静霞
黎兆军
机构
[1] 广东医学院附属医院皮肤科
关键词
水通道蛋白质3; 角质形成细胞; 皮肤疾病; 关系;
D O I
暂无
中图分类号
R751 [皮肤病学];
学科分类号
100227 [皮肤病学];
摘要
水通道蛋白3(AQP3)是一种细胞膜上跨膜运输水、甘油和尿素等小分子物质的转运蛋白,是人类皮肤中表达最多的一种水通道蛋白亚型。AQP3不仅参与皮肤水合、皮肤屏障功能以及创伤愈合,维持皮肤的正常形态和功能,还与角质形成细胞的增殖和迁移甚至早期分化有关;AQP3的表达下调参与非曝光部位皮肤的自然老化。AQP3与特应性皮炎、白癜风、皮肤肿瘤、银屑病等多种皮肤病的发病机制相关。AQP3的多种作用使其成为相关皮肤疾病治疗和护肤品研发的新靶点。
引用
收藏
页码:3101 / 3103
页数:3
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