骨髓间充质干细胞移植治疗脊髓损伤的应用技术

被引：4

作者：

王格 ^{[1
]}

武栋成 ^{[2
,3
]}

机构：

[1] 武汉大学

[2] 武汉大学生物化学系

[3] 武汉红桥脑科医院

来源：

中国组织工程研究 | 2012年 / 16卷 / 23期

关键词：

脊髓损伤; 骨髓间充质干细胞; 细胞移植; 研究; 治疗; 干细胞;

D O I：

暂无

中图分类号：

R651.2 [脊髓];

学科分类号：

100223 [神经外科学];

摘要：

背景:目前临床上对脊髓损伤患者脊神经的萎缩与坏死缺乏有效的修复方法。研究发现干细胞移植治疗脊髓损伤具有广阔的应用前景。目的:综述骨髓间充质干细胞移植治疗脊髓损伤的研究进展。方法:由第一作者检索2001/2011PubMed数据库(http://www.ncbi.nlm.nih.gov/PubMed)及万方数据库(http://g.wanfangdata.com.cn/)有关骨髓间充质干细胞、脊髓损伤、细胞移植等方面的文章,英文检索词为"bone marrow mesenchymal stem cells,spinal cord injury,cell transplantation",排除重复性研究,共保留其中的32篇文献进行归纳总结。结果与结论:骨髓间充质干细胞移植治疗脊髓损伤的研究在脊髓损伤模型制作、移植时间、移植方式、移植浓度、联合移植等多方面取得了成就,临床实验在国内外也已有所开展。但移植机制仍不十分明确,临床移植治疗的安全性和疗效需进一步研究。

引用

页码：4354 / 4358

页数：5

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