慢性药物性肝损伤研究进展

被引:7
作者
周天慧
谢青
机构
[1] 上海交通大学医学院附属瑞金医院感染科
关键词
D O I
10.14000/j.cnki.issn.1008-1704.2018.09.027
中图分类号
R575 [肝及胆疾病];
学科分类号
100201 [内科学];
摘要
<正>药物诱导的肝损伤(drug-induced liver injury,DILI)可表现为各种形式的急、慢性肝损伤。停用可疑药物后,大多数DILI为自限性,同时也有一部分患者仍可存在持续性的肝损伤,进而进展为慢性DILI[1]。DILI根据其致病药物特点,可分为固有型和特异质型,前者主要是由药物的直接毒性作用引起,如对乙酰氨基酚(APAP)等,是一种剂量依赖性的肝损伤,
引用
收藏
页码:825 / 827
页数:3
相关论文
共 27 条
[1]
Histopathological challenges in suspected drug-induced liver injury [J].
Kleiner, David E. .
LIVER INTERNATIONAL, 2018, 38 (02) :198-209
[2]
Autoimmune-Like Chronic Hepatitis Induced by Olmesartan [J].
Barge, Sandrine ;
Ziol, Marianne ;
Nault, Jean-Charles .
HEPATOLOGY, 2017, 66 (06) :2086-2088
[3]
Definition and risk factors for chronicity following acute idiosyncratic drug-induced liver injury [J].
Medina-Caliz, Inmaculada ;
Robles-Diaz, Mercedes ;
Garcia-Munoz, Beatriz ;
Stephens, Camilla ;
Ortega-Alonso, Aida ;
Garcia-Cortes, Miren ;
Gonzalez-Jimenez, Andres ;
Sanabria-Cabrera, Judith A. ;
Moreno, Inmaculada ;
Carmen Fernandez, M. ;
Romero-Gomez, Manuel ;
Navarro, Jose M. ;
Barriocanal, Ana Ma ;
Montane, Eva ;
Hallal, Hacibe ;
Blanco, Sonia ;
Soriano, German ;
Roman, Eva M. ;
Gomez-Dominguez, Elena ;
Castiella, Agustin ;
Zapata, Eva M. ;
Jimenez-Perez, Miguel ;
Moreno, Jose M. ;
Aldea-Perona, Ana ;
Hernandez-Guerra, Manuel ;
Prieto, Martin ;
Zoubek, Miguel E. ;
Kaplowitz, Neil ;
Isabel Lucena, M. ;
Andrade, Raul J. .
JOURNAL OF HEPATOLOGY, 2016, 65 (03) :532-542
[4]
Chronic liver injury induced by drugs: a systematic review [J].
Stine, Jonathan G. ;
Chalasani, Naga .
LIVER INTERNATIONAL, 2015, 35 (11) :2343-2353
[5]
Transitioning from Idiopathic to Explainable Autoimmune Hepatitis [J].
Czaja, Albert J. .
DIGESTIVE DISEASES AND SCIENCES, 2015, 60 (10) :2881-2900
[6]
Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study [J].
Chalasani, Naga ;
Bonkovsky, Herbert L. ;
Fontana, Robert ;
Lee, William ;
Stolz, Andrew ;
Talwalkar, Jayant ;
Reddy, K. Rajendar ;
Watkins, Paul B. ;
Navarro, Victor ;
Barnhart, Huiman ;
Gu, Jiezhun .
GASTROENTEROLOGY, 2015, 148 (07) :1340-+
[7]
Spectrum of Statin Hepatotoxicity: Experience of the Drug-Induced Liver Injury Network [J].
Russo, Mark W. ;
Hoofnagle, Jay H. ;
Gu, Jiezhun ;
Fontana, Robert J. ;
Barnhart, Huiman ;
Kleiner, David E. ;
Chalasani, Naga ;
Bonkovsky, Herbert L. .
HEPATOLOGY, 2014, 60 (02) :679-686
[8]
ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury [J].
Chalasani, Naga P. ;
Hayashi, Paul H. ;
Bonkovsky, Herbert L. ;
Navarro, Victor J. ;
Lee, William M. ;
Fontana, Robert J. .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2014, 109 (07) :950-966
[9]
Idiosyncratic Drug-Induced Liver Injury Is Associated With Substantial Morbidity and Mortality Within 6 Months From Onset [J].
Fontana, Robert J. ;
Hayashi, Paul H. ;
Gu, Jiezhun ;
Reddy, K. Rajender ;
Barnhart, Huiman ;
Watkins, Paul B. ;
Serrano, Jose ;
Lee, William M. ;
Chalasani, Naga ;
Stolz, Andrew ;
Davern, Timothy ;
Talwakar, Jayant A. .
GASTROENTEROLOGY, 2014, 147 (01) :96-U189
[10]
Diagnosis and classification of drug-induced autoimmunity (DIA) [J].
Xiao, Xiao ;
Chang, Christopher .
JOURNAL OF AUTOIMMUNITY, 2014, 48-49 :66-72