ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury

被引：685

作者：

Chalasani, Naga P. ^{[1
]}

Hayashi, Paul H. ^{[2
]}

Bonkovsky, Herbert L. ^{[3
]}

Navarro, Victor J. ^{[4
]}

Lee, William M. ^{[5
]}

Fontana, Robert J. ^{[6
]}

机构：

[1] Indiana Univ Sch Med, Indianapolis, IN 46202 USA

[2] Univ N Carolina, Chapel Hill, NC USA

[3] CarolinasHealthCare Syst, Charlotte, NC USA

[4] Einstein Hlth Care Network, Philadelphia, PA USA

[5] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA

[6] Univ Michigan, Ann Arbor, MI 48109 USA

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2014年 / 109卷 / 07期

基金：

美国国家卫生研究院;

关键词：

INTRAVENOUS N-ACETYLCYSTEINE; CAUSALITY ASSESSMENT; VENOOCCLUSIVE DISEASE; HEPATITIS-C; ADVERSE REACTIONS; AMERICAN-COLLEGE; HEPATOTOXICITY; OUTCOMES; FAILURE; METHOTREXATE;

D O I：

10.1038/ajg.2014.131

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Idiosyncratic drug-induced liver injury (DILI) is a rare adverse drug reaction and it can lead to jaundice, liver failure, or even death. Antimicrobials and herbal and dietary supplements are among the most common therapeutic classes to cause DILI in the Western world. DILI is a diagnosis of exclusion and thus careful history taking and thorough work-up for competing etiologies are essential for its timely diagnosis. In this ACG Clinical Guideline, the authors present an evidence-based approach to diagnosis and management of DILI with special emphasis on DILI due to herbal and dietary supplements and DILI occurring in individuals with underlying liver disease.

引用

收藏

页码：950 / 966

页数：17

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