苯并咪唑类酶抑制剂研究进展

被引：53

作者：

孟江平

卢一卉

海力且木·依不那音

周成合

机构：

[1] 西南大学化学化工学院

来源：

中国生化药物杂志 | 2008年 / 29卷 / 06期

关键词：

苯并咪唑; 酶抑制剂;

D O I：

暂无

中图分类号：

TQ463.53 [];

学科分类号：

摘要：

苯并咪唑类化合物能对众多酶起到抑制作用,从而产生良好的药理效应。目前,有关苯并咪唑作为酶抑制剂的研究较为活跃,进展迅速,并取得了一系列新的研究成果。此文综述苯并咪唑类化合物在酶抑制剂领域的研究与进展情况。

引用

收藏

页码：418 / 421

页数：4

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共 10 条

[1]

磺胺类碳酸酐酶抑制剂研究进展 [J].

宋春泽 ;

周成合 ;

袁勇 .

中国新药杂志, 2007, (18) :1438-1444

[2]

南瓜胰蛋白酶抑制剂 [J].

徐扬 ;

王凤山 .

中国生化药物杂志, 2006, (01) :49-51

[3]

Dihydropyrrolopyrazole transforminggrowth factor-βtypeⅠreceptor kinase domain inhibitors:A novel benz-imidazole series with selectivity versus transforming growth factor-betatypeⅡreceptor kinase and mixed lineage kinase-7..Li H Y;Wang Y;Heap C R;et al;.J Med Chem.2006, 06

[4]

Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCVNS5B polymerase:: From benzimidazole to indole scaffolds [J].

Beaulieu, Pierre L. ;

Gillard, James ;

Bykowski, Darren ;

Brochu, Christian ;

Dansereau, Nathalie ;

Duceppe, Jean-Simon ;

Haché, Bruno ;

Jakalian, Araz ;

Lagacé, Lisette ;

LaPlante, Steven ;

McKercher, Ginette ;

Moreau, Elaine ;

Perreault, Stphane ;

Stammers, Timothy ;

Thauvette, Louise ;

Warrington, Jeff ;

Kukolj, George .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (19) :4987-4993

[5]

3-benzimidazol-2-yl-1H-indazoles as potent c-ABL inhibitors [J].

McBride, Christopher M. ;

Renhowe, Paul A. ;

Gesner, Thomas G. ;

Jansen, Johanna M. ;

Lin, Julie ;

Ma, Sylvia ;

Zhou, Yasheen ;

Shafer, Cynthia M. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (14) :3789-3792

[6]

3D-QSAR analysis on benzazole derivatives as eukaryotic topoisomerase II inhibitors by using comparative molecular field analysis method [J].

Temiz-Arpaci, O ;

Tekiner-Gulbas, B ;

Yildiz, I ;

Aki-Sener, E ;

Yalcin, I .

BIOORGANIC & MEDICINAL CHEMISTRY, 2005, 13 (23) :6354-6359

[7]

Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors [J].

White, AW ;

Curtin, NJ ;

Eastman, BW ;

Golding, BT ;

Hostomsky, Z ;

Kyle, S ;

Li, J ;

Maegley, KA ;

Skalitzky, DJ ;

Webber, SE ;

Yu, XH ;

Griffin, RJ .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (10) :2433-2437

[8]

Design, synthesis and biological evaluation of benzimidazole/benzothiazole and benzoxazole derivatives as cyclooxygenase inhibitors [J].

Paramashivappa, R ;

Kumar, PP ;

Rao, PVS ;

Rao, AS .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (04) :657-660

[9]

Mechanistic and anti-proliferative studies of two novel, biologically active bis-benzimidazoles [J].

Seaton, A ;

Higgins, C ;

Mann, J ;

Baron, A ;

Bailly, C ;

Neidle, S ;

van den Berg, H .

EUROPEAN JOURNAL OF CANCER, 2003, 39 (17) :2548-2555

[10]

Some new bi- and ter-benzimidazole derivatives as topoisomerase I inhibitors.[J]..Il Farmaco.2003, 7