IL-17结构及其信号通路与肿瘤的关系

被引：18

作者：

地力下司马义 ^{[1
]}

李锋 ^{[1
,2
]}

张文杰 ^{[1
,2
]}

机构：

[1] 石河子大学医学院病理学教研室

[2] 石河子大学医学院新疆地方与民族高发病教育部重点实验室

来源：

农垦医学 | 2012年 / 34卷 / 02期

关键词：

IL-17; 信号通路; 肿瘤;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 [肿瘤学];

摘要：

IL-17的发现已有20年,IL-17由CD4+T细胞分泌的一种细胞因子。TH17细胞分泌的IL-17结合于靶细胞后可以促进炎症趋化因子、急性期蛋白、中性粒细胞聚集,从而在机体免疫和自身免疫性疾病中发挥作用。在风湿性关节炎,系统性红斑狼疮,银屑病等的研究发现在这些疾病中均存在IL-17的高表达,IL-17与其他分子协同作用在自身免疫性疾病的发病机制中具有重要作用。同时在宫颈癌,黑色素瘤,乳腺癌等的研究中均发现存在IL-17的高表达。IL-17可以促进慢性炎症的进展,引起组织增生,促进组织癌变,促进肿瘤新生血管生成。对IL-17及其信号通路的研究深入,可以为肿瘤的分子靶向治疗提供新的思路。

引用

收藏

页码：166 / 171

页数：6

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