基质金属蛋白酶(MMPS)与椎间盘退变相关性的研究进展

被引：8

作者：

卢家灵

机构：

[1] 广西省贵港市中西医结合骨科医院

来源：

中国医学创新 | 2015年 / 12卷 / 16期

关键词：

基质金属蛋白酶; 椎间盘退变; 相关性; 研究进展;

D O I：

暂无

中图分类号：

R681.53 [];

学科分类号：

摘要：

有证据表明,MMPs(Matrix Metalloproteinases)在椎间盘退变(IVDD)中起着重要作用,能加速椎间盘细胞外基质(ECM,extracell matrix)的退变进程,也有大量免疫组化证据的支持。目前MMPs、TIMPs与IVDD相关性的基础研究很多,是颈肩腰腿痛预防、诊断、干预和治疗的基础研究热点,本文就MMPs在IVDD作用相关性的研究进展做一综述。

引用

收藏

页码：151 / 154

页数：4

相关论文

共 28 条

[1]

Genetics of the Degenerated Intervertebral Disc [J].

Kalb, Samuel ;

Martirosyan, Nikolay L. ;

Kalani, M. Yashar S. ;

Broc, Guy G. ;

Theodore, Nicholas .

WORLD NEUROSURGERY, 2012, 77 (3-4) :491-501

[2]

Cell viability in intervertebral disc under various nutritional and dynamic loading conditions: 3d Finite element analysis [J].

Zhu, Qiaoqiao ;

Jackson, Alicia R. ;

Gu, Wei Yong .

JOURNAL OF BIOMECHANICS, 2012, 45 (16) :2769-2777

[3]

Role of mitochondrial pathway in compression-induced apoptosis of nucleus pulposus cells [J].

Ding, Fan ;

Shao, Zeng-Wu ;

Yang, Shu-Hua ;

Wu, Qiang ;

Gao, Fei ;

Xiong, Li-Ming .

APOPTOSIS, 2012, 17 (06) :579-590

[4]

Effect of Shear Force on Intervertebral Disc (IVD) Degeneration: An In Vivo Rat Study [J].

Kim, Jaehyun ;

Yang, Seok-Jo ;

Kim, Hyunchul ;

Kim, Yoonsang ;

Park, Joon B. ;

DuBose, Candis ;

Lim, Tae-Hong .

ANNALS OF BIOMEDICAL ENGINEERING, 2012, 40 (09) :1996-2004

[5]

Expression of Fas receptor and apoptosis in vertebral endplates with degenerative disc diseases categorized as Modic type I or II [J].

Wang, Fei ;

Jiang, Jian-Ming ;

Deng, Chen-Hong ;

Wang, Feng-Long ;

Fu, Zhao-Zong ;

Zhang, Zhao-Fei .

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 2011, 42 (08) :790-795

[6]

Matrix metalloproteinase expression levels suggest distinct enzyme roles during lumbar disc herniation and degeneration [J].

Bachmeier, Beatrice E. ;

Nerlich, Andreas ;

Mittermaier, Norbert ;

Weiler, Christoph ;

Lumenta, Christianto ;

Wuertz, Karin ;

Boos, Norbert .

EUROPEAN SPINE JOURNAL, 2009, 18 (11) :1573-1586

[7]

Increased MMP-2 activity during intervertebral disc degeneration is correlated to MMP-14 levels [J].

Rutges, J. P. H. J. ;

Kummer, J. A. ;

Oner, F. C. ;

Verbout, A. J. ;

Castelein, R. J. M. ;

Roestenburg, H. J. A. ;

Dhert, W. J. A. ;

Creemers, L. B. .

JOURNAL OF PATHOLOGY, 2008, 214 (04) :523-530

[8]

Vertebral Endplate and disc changes in the aging sand rat lumbar spine - Cross-sectional analyses of a large male and female population [J].

Gruber, Helen E. ;

Gordon, Brian ;

Williams, Cliff ;

Norton, James ;

Hanley, Edward N., Jr. .

SPINE, 2007, 32 (23) :2529-2536

[9]

Modic changes in endplates of lumbar vertebral bodies -: Prevalence and association with low back and sciatic pain among middle-aged male workers [J].

Kuisma, Mari ;

Karppinen, Jaro ;

Niinimaki, Jaakko ;

Ojala, Risto ;

Haapea, Marianne ;

Heliovaara, Markku ;

Korpelainen, Raija ;

Taimela, Simo ;

Natri, Antero .

SPINE, 2007, 32 (10) :1116-1122

[10]

ISSLS prize winner: A study of diffusion in human lumbar discs: A serial magnetic resonance imaging study documenting the influence of the endplate on diffusion in normal and degenerate discs [J].

Rajasekaran, S ;

Babu, JN ;

Arun, R ;

Armstrong, BRW ;

Shetty, AP ;

Murugan, S .

SPINE, 2004, 29 (23) :2654-2667