骨性关节炎与整合素-FAK力学信号转导通路的基础研究

被引：12

作者：

夏鹏

李雪萍

机构：

[1] 南京医科大学附属南京医院南京市第一医院康复医学科

来源：

中华临床医师杂志(电子版) | 2012年 / 6卷 / 24期

关键词：

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

<正>骨性关节炎(osteoarthritis,OA)是一种常见的由于关节软骨退行性变引起的疾病,好发于中老年人,其病因及发病机制尚不明确,组织病理学上主要以关节软骨的丢失,骨赘形成,软骨下骨的增厚以及软骨下骨囊性变为特征,是不同因素作用所致的不可逆关节损害,临床表现为关节疼痛、僵直畸形和功能障碍[1-3]。相关研究表明,机械应力是维持骨骼系统的最重要生理

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页码：8245 / 8248

页数：4

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