雄黄抗肿瘤作用的研究进展

被引：15

作者：

伏旭

李培武

尹稳

机构：

[1] 兰州大学第二医院

来源：

沈阳药科大学学报 | 2016年 / 33卷 / 11期

关键词：

雄黄; 抗肿瘤; 增殖; 凋亡; 纳米雄黄;

D O I：

10.14066/j.cnki.cn21-1349/r.2016.11.013

中图分类号：

R285.5 [中药实验药理];

学科分类号：

100806 [中药药理学];

摘要：

目的综述了近年来雄黄（As4S4）在体内和体外治疗各种肿瘤的应用近况及其药理作用。方法查阅相关文献43篇,对雄黄（As4S4）在临床上的应用以及其在体内和体外治疗各种肿瘤的应用现状和药理作用进行了归纳总结。结果雄黄（As4S4）在临床能够用于治疗血液疾病、关节疾病及皮肤病（外用）,能够通过多种途径抑制多种肿瘤细胞的增殖和诱导凋亡。结论雄黄（As4S4）在多种肿瘤相关疾病的治疗方面具有广阔的应用前景。

引用

页码：914 / 920

页数：7

共 36 条

[1]

Arsenic disulfide-triggered apoptosis and erythroid differentiation in myelodysplastic syndrome and acute myeloid leukemia cell lines [J].

Hu, Xiao-Mei ;

Yuan, Bo ;

Tanaka, Sachiko ;

Song, Min-Min ;

Onda, Kenji ;

Tohyama, Kaoru ;

Zhou, Ai-Xiang ;

Toyoda, Hiroo ;

Hirano, Toshihiko .

HEMATOLOGY, 2014, 19 (06) :352-360

[2]

Arsenic disulfide induces apoptosis of human diffuse large B cell lymphoma cells involving Bax cleavage [J].

Wang, Ling ;

Liu, Xinyu ;

Li, Xianglu ;

Lv, Xiao ;

Lu, Kang ;

Chen, Na ;

Li, Peipei ;

Wang, Xin .

ONCOLOGY REPORTS, 2013, 30 (05) :2427-2434

[3]

Realgar induces apoptosis in the chronic lymphocytic leukemia cell line MEC-1 [J].

Liu, Xinyu ;

Li, Xianglu ;

Wang, Ling ;

Lv, Xiao ;

Chen, Na ;

Li, Peipei ;

Lu, Kang ;

Wang, Xin .

MOLECULAR MEDICINE REPORTS, 2013, 8 (06) :1866-1870

[4]

The Research of Nanocrystallized Realgar for the Treatment of Skin Cancer.[J].Yuanfu Qi;Xiurong Li;Huijie Li;Yi Zheng.Journal of Cancer Therapy.2013, 06

[5]

Realgar-induced apoptosis and differentiation in all-trans retinoic acid (ATRA)-sensitive NB4 and ATRA-resistant MR2 cells [J].

Chen, Siyu ;

Fang, Yi ;

Ma, Liheng ;

Liu, Shanxi ;

Li, Xinmin .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2012, 40 (04) :1089-1096

[6]

Effect of size and processing method on the cytotoxicity of realgar nanoparticles in cancer cell lines.[J].Weizhong Zhao;Yang;Liu;Yuan Yuan;Lu;Weizhong Zhao;Hong;Wang;Zeng.International Journal of Nanomedicine.2011, defa

[7]

Anticancer effect of realgar nanoparticles on mouse melanoma skin cancer in vivo via transdermal drug delivery [J].

Zhao, Qi-Hong ;

Zhang, Ying ;

Liu, Yun ;

Wang, Hui-Li ;

Shen, Yuan-Yuan ;

Yang, Wen-Jun ;

Wen, Long-Ping .

MEDICAL ONCOLOGY, 2010, 27 (02) :203-212

[8]

Realgar-induced differentiation is associated with MAPK pathways in HL-60 cells [J].

Wang, Nan ;

Wang, Li-Wen ;

Gou, Bao-Di ;

Zhang, Tian-Lan ;

Wang, Kui .

CELL BIOLOGY INTERNATIONAL, 2008, 32 (12) :1497-1505

[9]

Ascorbic acid and α-tocopherol as potent modulators of apoptosis on arsenic induced toxicity in rats.[J].Kadirvel Ramanathan;Muthuswamy Anusuyadevi;Samuel Shila;Chinnakannu Panneerselvam.Toxicology Letters.2004, 2

[10]

Arsenic trioxide-induced apoptosis through oxidative stress in cells of colon cancer cell lines [J].

Nakagawa, Y ;

Akao, Y ;

Morikawa, H ;

Hirata, I ;

Katsu, K ;

Naoe, T ;

Ohishi, N ;

Yagi, K .

LIFE SCIENCES, 2002, 70 (19) :2253-2269

← 1 2 3 4 →