广州地区中老年男性RANK/RANKL/OPG和WNT信号通路基因多态性与髋部骨强度的关联分析

被引：7

作者：

王希丹

肖苏妹

陈裕明

机构：

[1] 中山大学公共卫生学院

来源：

生命科学研究 | 2018年 / 22卷 / 02期

基金：

广州市科技计划项目; 广东省自然科学基金;

关键词：

RANK/RANKL/OPG信号通路; WNT信号通路; 基因多态性; 髋部骨密度; 髋部骨几何结构;

D O I：

10.16605/j.cnki.1007-7847.2018.02.008

中图分类号：

R580 [];

学科分类号：

摘要：

为了探讨RANK/RANKL/OPG和WNT信号通路中6个基因10个单核苷酸多态性位点与中老年男性髋部骨强度的关联,征集788名广州地区40岁以上男性为研究对象,采用Mass Array检测基因型,双能X线吸收仪测定股骨颈骨密度（bone mineral density,BMD）、横截面积（cross-sectional area,CSA）、平均皮质厚度（average cortical thickness,ACT）、剖面模数（section modulus,SM）和抗屈曲率（buckling ratio,BR）,以多重线性回归分析各位点与骨表型的关联。结果发现:OPG基因rs3134069的C等位基因与BMD（β=-0.017,P=0.024）和ACT（β=-0.004,P=0.040）负相关;LRP5基因rs3736228的T等位基因与低BMD、CSA、ACT（β=-0.050-0.003,P<0.050）和高BR（β=0.242,P=0.043）相关,rs491347的G等位基因与低BMD相关（β=-0.012,P=0.046）。研究结果支持了OPG和LRP5基因与中国中老年男性人群髋部骨强度相关。

引用

页码：143 / 148

页数：6

共 16 条

[1]

The WNT system: background and its role in bone [J].

Lerner, U. H. ;

Ohlsson, C. .

JOURNAL OF INTERNAL MEDICINE, 2015, 277 (06) :630-649

[2]

TNFRSF11B gene polymorphisms, bone mineral density, and fractures in Slovak postmenopausal women [J].

Boronova, Iveta ;

Bernasovska, Jarmila ;

Macekova, Sona ;

Petrejcikova, Eva ;

Tomkova, Zlatica ;

Kl'oc, Jan ;

Poracova, Janka ;

Blascakova, Marta Mydlarova ;

Litavcova, Eva .

JOURNAL OF APPLIED GENETICS, 2015, 56 (01) :57-63

[3]

Association between dietary intake of flavonoid and bone mineral density in middle aged and elderly Chinese women and men [J].

Zhang, Z. -q. ;

He, L. -p. ;

Liu, Y. -h. ;

Liu, J. ;

Su, Y. -x. ;

Chen, Y. -m. .

OSTEOPOROSIS INTERNATIONAL, 2014, 25 (10) :2417-2425

[4]

Does Bone Resorption Stimulate Periosteal Expansion? A Cross‐Sectional Analysis of β‐C‐telopeptides of Type I Collagen (CTX); Genetic Markers of the RANKL Pathway; and Periosteal Circumference as Measured by pQCT.[J].John P Kemp;Adrian Sayers;Lavinia Paternoster;David M Evans;Kevin Deere;Beate St Pourcain;Nicholas J Timpson;Susan M Ring;Mattias Lorentzon;Terho Lehtim?ki;Joel Eriksson;Mika K?h?nen;Olli Raitakari;Marika Laaksonen;Harri Siev?nen;Jorma Viikari;Leo‐Pekka Lyytik?inen;George Davey Smit

[5]

Association of genetic polymorphisms of RANK, RANKL and OPG with bone mineral density in Chinese peri- and postmenopausal women [J].

Shang, Min ;

Lin, Li ;

Cui, Hong .

CLINICAL BIOCHEMISTRY, 2013, 46 (15) :1493-1501

[6]

Genetic and environmental factors in human osteoporosis [J].

Ozbas, Halil ;

Onrat, Serap Tutgun ;

Ozdamar, Kazim .

MOLECULAR BIOLOGY REPORTS, 2012, 39 (12) :11289-11296

[7]

Susceptibility Genes for Osteoporotic Fracture in Postmenopausal Chinese Women [J].

Wang, Chun ;

Zhang, Zeng ;

Zhang, Hao ;

He, Jin-Wei ;

Gu, Jie-Mei ;

Hu, Wei-Wei ;

Hu, Yun-Qiu ;

Li, Miao ;

Liu, Yu-Juan ;

Fu, Wen-Zhen ;

Yue, Hua ;

Ke, Yao-Hua ;

Zhang, Zhen-Lin .

JOURNAL OF BONE AND MINERAL RESEARCH, 2012, 27 (12) :2582-2591

[8]

TNFRSF11B gene polymorphisms 1181G<ce:hsp sp="0.25"/>><ce:hsp sp="0.25"/>C and 245T<ce:hsp sp="0.25"/>><ce:hsp sp="0.25"/>G as well as haplotype CT influence bone mineral density in postmenopausal women.[J]..Maturitas.2011, 3

[9]

Receptor activator of nuclear factor-κB ligand and osteoprotegerin: maintaining the balance to prevent bone loss.[J].Vincent Goeb;Trouvin Anne-Priscille.Clinical Interventions in Aging.2010, defa

[10]

The differences of femoral neck geometric parameters: effects of age, gender and race [J].

Zhang, F. ;

Tan, L. -J. ;

Lei, S. -F. ;

Deng, H. -W. .

OSTEOPOROSIS INTERNATIONAL, 2010, 21 (07) :1205-1214

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