Wnt信号通路抑制因子DKK-1在骨质疏松发生中的研究进展

被引：16

作者：

罗磊

谭钢

康鹏德

廉永运

裴福兴

机构：

[1] 四川大学华西医院骨科

来源：

中国骨质疏松杂志 | 2010年 / 16卷 / 05期

关键词：

Wnt信号通路; DKK-1; 骨质疏松;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

Wnt信号通路对成骨细胞的发育及分化起着重要作用。近年来的研究发现,作为Wnt信号通路的抑制因子DKK-1能抑制骨形成,导致骨质疏松,而通过拮抗DKK-1的作用可使骨量增加。DKK-1可能成为治疗骨质疏松的新靶点。笔者对DKK-1在成骨细胞中的信号传导途径及其在骨质疏松中的作用做了综述。

引用

页码：365 / 368

页数：4

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