β-catenin:: a key mediator of Wnt signaling

被引：813

作者：

Willert, K ^{[1
]}

Nusse, R ^{[1
]}

机构：

[1] Stanford Univ, Med Ctr, Howard Hughes Med Inst, Dept Dev Biol, Stanford, CA 94305 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1998年 / 8卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(98)80068-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

beta-catenin is a pivotal player in the signaling pathway initiated by Wnt proteins, mediators of several developmental processes. beta-catenin activity is controlled by a large number of binding partners that affect the stability and the localization of beta-catenin and is thereby able to participate in such varying processes as gene expression and cell adhesion. Activating mutations in beta-catenin and in components regulating its stability can contribute to the formation of certain tumors.

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页码：95 / 102

页数：8

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