非酒精性脂肪肝、隐源性肝硬化与原发性肝癌发生的关系

被引:11
作者
钟黄 [1 ]
李良平 [2 ]
韩盛玺 [2 ]
机构
[1] 遵义医学院级消化内科
[2] 四川省医学科学院四川省人民医院消化内科
关键词
隐源性肝硬化; 原发性肝癌; 非酒精性脂肪肝; 肝细胞癌;
D O I
暂无
中图分类号
R735.7 [肝肿瘤]; R575.5 [肝代谢障碍]; R575.2 [肝硬变];
学科分类号
100214 ; 1002 ; 100201 ;
摘要
临床研究发现,大部分原因不明的隐源性肝硬化由非酒精性脂肪性肝病发展而来,甚至有些最后发展成原发性肝癌,此文主要综述原发性肝癌伴隐源性肝硬化的发生率、隐源性肝硬化的病因、非酒精性脂肪性肝炎发展至原发性肝癌的发病机制、危险因素、临床特点及诊断治疗方法。
引用
收藏
页码:402 / 405
页数:4
相关论文
共 13 条
[1]  
肝癌发生过程中的差异基因表达[J]. 白阳秋,丁光伟,杨玉秀.世界华人消化杂志. 2008(22)
[2]  
Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis[J]. Yusuf Yilmaz,Enver Dolar,Engin Ulukaya,Semra Akgoz,Murat Keskin,Murat Kiyici,Sibel Aker,Arzu Yilmaztepe,Selim Gurel,Macit Gulten,Selim Giray Nak.World Journal of Gastroenterology. 2007(06)
[3]  
Molecular mechanisms involved in NAFLD progression[J] . Mariano Malaguarnera,Michelino Rosa,Ferdinando Nicoletti,Lucia Malaguarnera.Journal of Molecular Medicine . 2009 (7)
[4]   Mechanisms of Disease Progression in Nonalcoholic Fatty Liver Disease [J].
Jou, Janice ;
Choi, Steve S. ;
Diehl, Anna Mae .
SEMINARS IN LIVER DISEASE, 2008, 28 (04) :370-379
[5]   Hepatocellular carcinoma in patients with nonalcoholic steatohepatitis [J].
Etsuko Hashimoto ;
Satoru Yatsuji ;
Maki Tobari ;
Makiko Taniai ;
Nobuyuki Torii ;
Katsutoshi Tokushige ;
Keiko Shiratori .
Journal of Gastroenterology, 2009, 44 :89-95
[6]   Primary liver cancers with nonalcoholic steatohepatitis [J].
Hashizume, Hiroaki ;
Sato, Ken ;
Takagi, Hitoshi ;
Hirokawa, Tomoyuki ;
Kojima, Akira ;
Sohara, Naondo ;
Kakizaki, Satoru ;
Mochida, Yasushi ;
Shimura, Tatsuo ;
Sunose, Yutaka ;
Ohwada, Susumu ;
Mori, Masatomo .
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2007, 19 (10) :827-834
[7]  
Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis[J] . Hashem B. El–Serag,K. Lenhard Rudolph.Gastroenterology . 2007 (7)
[8]   NASH and the risk of cirrhosis and hepatocellular carcinoma in type 2 diabetes [J].
Bugianesi E. ;
Vanni E. ;
Marchesini G. .
Current Diabetes Reports, 2007, 7 (3) :175-180
[9]  
Non‐alcoholic steatohepatitis and hepatocellular carcinoma: Lessons from hepatocyte‐specific phosphatase and tensin homolog (PTEN)‐deficient mice[J] . SumioWatanabe,YasuoHorie,EiKataoka,WataruSato,TakahiroDohmen,ShigetoshiOhshima,TakashiGoto,AkiraSuzuki.Journal of Gastroenterology and Hepatology . 2007
[10]   Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma [J].
El-Serag, HB ;
Tran, T ;
Everhart, JE .
GASTROENTEROLOGY, 2004, 126 (02) :460-468