五羟色胺2A受体基因-环境交互作用与抑郁伴自杀关联研究

被引：7

作者：

宋珺瑶

杨艳杰

王琳

马靖松

刘玥汐

王鹏

杨秀贤

邱晓惠

乔正学

机构：

[1] 哈尔滨医科大学公共卫生学院医学心理学教研室

来源：

中华行为医学与脑科学杂志 | 2015年 / 24卷 / 04期

关键词：

抑郁伴自杀; 五羟色胺2A受体基因; 基因-环境交互作用;

D O I：

暂无

中图分类号：

R749.4 [情感性精神病]; B846 [变态心理学、病态心理学、超意识心理学];

学科分类号：

040203 ;

摘要：

目的探讨五羟色胺2A受体(5-hydroxytrytamine receptor 2A, 5-HTR2A)基因多态性、负性生活事件交互作用与抑郁伴自杀的关系。方法提取中国北方地区130名抑郁伴自杀者(病例组)和118名抑郁无自杀者(对照组)基因组DNA, 采用Snapshot技术分别扩增rs6311和rs6313位点的基因组DNA片段, 将PCR产物直接测序检测病例组和对照组的基因型, 应用二分类Logistic回归模型分析rs6311、rs6313与负性生活事件的交互作用。结果病例组与对照组rs6311位点的基因型(χ2=0.012)和等位基因频率(χ2=0.062)比较均差异无统计学意义(P>0.05)。两组rs6313位点的基因型比较, 差异无统计学意义(χ2=1.035, P>0.05), 但等位基因频率比较差异有统计学意义(等位基因A: 73.1%vs 50.4%;等位基因G:26.9%vs 49.6%;χ2=27.029, P<0.05)。rs6311和负性生活事件交互作用差异有统计学意义(OR=6.155, 95%CI=1.372～27.612, P<0.05)。rs6313和负性生活事件交互作用差异无统计学意义(OR=0.772, 95%CI=0.231～2.579, P>0.05)。结论 rs6311与负性生活事件的交互作用在抑郁伴自杀的发病机制中具有重要意义。

引用

页码：307 / 309

页数：3

共 16 条

[1]

5-HT2A受体T102C基因多态性与农村自杀未遂的关系研究.[D].廉颖.山东大学.2013, 11

[2]

Interactions between a serotonin transporter gene; life events and social support on suicidal ideation in Korean elders.[J].Jae-Min Kim;Robert Stewart;Sung-Wan Kim;Hee-Ju Kang;Seon-Young Kim;Ju-Yeon Lee;Kyung-Yeol Bae;Il-Seon Shin;Jin-Sang Yoon.Journal of Affective Disorders.2014,

[3] Gene environment interaction studies in depression and suicidal behavior: An update [J].

Mandelli, Laura ;

Serretti, Alessandro .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2013, 37 (10) :2375-2397

[4] The serotonergic system in mood disorders and suicidal behaviour [J].

Mann, J. John .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2013, 368 (1615)

[5] Family-based study of HTR2A in suicide attempts: observed gene, gene x environment and parent-of-origin associations [J].

Ben-Efraim, Yj ;

Wasserman, D. ;

Wasserman, J. ;

Sokolowski, M. .

MOLECULAR PSYCHIATRY, 2013, 18 (07) :758-766

[6]

Gene environment interaction studies in depression and suicidal behavior: an update.[J].Laura Mandelli;Alessandro Serretti.Neuroscience and Biobehavioral Reviews.2013,

[7] Gene-environment interactions: early life stress and risk for depressive and anxiety disorders [J].

Nugent, Nicole R. ;

Tyrka, Audrey R. ;

Carpenter, Linda L. ;

Price, Lawrence H. .

PSYCHOPHARMACOLOGY, 2011, 214 (01) :175-196

[8] Childhood Maltreatment, the Corticotropin-Releasing Hormone Receptor Gene and Adult Depression in the General Population [J].

Grabe, Hans Joergen ;

Schwahn, Christian ;

Appel, Katja ;

Mahler, Jessie ;

Schulz, Andrea ;

Spitzer, Carsten ;

Fenske, Kristin ;

Barnow, Sven ;

Lucht, Michael ;

Freyberger, Harald Juergen ;

John, Ulrich ;

Teumer, Alexander ;

Wallaschofski, Henri ;

Nauck, Matthias ;

Voelzke, Henry .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2010, 153B (08) :1483-1493

[9]

Recent molecular genetic studies and methodological issues in suicide research.[J].Shih-Jen Tsai;Chen-Jee Hong;Ying-Jay Liou.Progress in Neuropsychopharmacology & Biological Psychiatry.2010, 4

[10] Sadness, Depression, and Avoidance Behavior [J].

Leventhal, Allan M. .

BEHAVIOR MODIFICATION, 2008, 32 (06) :759-779

← 1 2 →