乳酸异常代谢与肿瘤的研究进展

被引：20

作者：

赵宇

刘志刚

王晖

机构：

[1] 湖南省肿瘤医院·中南大学湘雅医学院附属肿瘤医院放疗科

来源：

中华肿瘤防治杂志 | 2015年 / 22卷 / 03期

关键词：

肿瘤乳酸代谢; 肿瘤细胞生物学行为; 个体化治疗; 综述文献;

D O I：

10.16073/j.cnki.cjcpt.2015.03.021

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 [肿瘤学];

摘要：

目的总结乳酸异常代谢与肿瘤细胞生物学行为、临床预后及个体化治疗的研究进展。方法应用Medline、PubMed及谷歌学术数据库检索系统,以"乳酸、肿瘤代谢、临床预后"为关键词,检索2000-2014年的相关文献。纳入标准:1)肿瘤细胞乳酸代谢;2)乳酸与肿瘤细胞生物学行为;3)乳酸与肿瘤临床预后;4)乳酸与肿瘤个体化治疗。根据纳入标准,符合分析的文献有25篇。结果肿瘤细胞能够通过无氧糖酵解利用葡萄糖产能,以满足其增生的能量需求。乳酸作为肿瘤细胞有氧糖酵解的主要代谢终产物,在细胞内和细胞间隙大量聚集,密切影响肿瘤细胞的生物学行为,并与放射敏感性、临床预后紧密相关。目前已有针对肿瘤细胞乳酸代谢的靶向药物进入临床试验阶段,为肿瘤治疗提供了新思路。结论肿瘤细胞异常乳酸代谢有希望成为肿瘤患者预后提示及个体化治疗的新靶点。

引用

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页码：239 / 242

页数：4

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