胰岛素受体底物家族成员的结构和组织特异性与功能的关系

被引：26

作者：

唐辰义

周后德

机构：

[1] 中南大学湘雅二医院代谢内分泌研究所

来源：

临床与病理杂志 | 2016年 / 36卷 / 03期

关键词：

胰岛素受体底物蛋白1-6; Src同源结构域2; 胰岛素信号通路;

D O I：

暂无

中图分类号：

R587.1 [糖尿病];

学科分类号：

100201 [内科学];

摘要：

胰岛素(insulin)/胰岛素样生长因子1(insulin-like growth factor 1,IGF-1)信号通路在细胞的分化、生长、生存及代谢起非常重要作用。胰岛素信号传递首先需要胰岛素/IGF-1与胰岛素受体(insulin receptor,IR)结合,磷酸化胰岛素受体底物(insulin receptor substrates,IR Ss)后形成一个紧密连接的三聚物。磷酸化的IRSs作为停靠蛋白(docking protein)再激活一系列包含Src同源结构域2(SH2)的蛋白,引起相应的生物学效应。目前发现IRSs从IRS-1到IRS-6共6种,它们的分布存在明显的组织特异性,IRS-1、2在人体多种组织中分布广泛;IRS-3则在脂肪组织中居多;而IRS-4、5、6在人体组织表达相对较低。本文拟对IRSs在组织中分布特异性与功能作一综述。

引用

页码：295 / 302

页数：8

共 19 条

[1]

Novel compounds reducing IRS-1 serine phosphorylation for treatment of diabetes [J].

Simon-Szabo, Laura ;

Kokas, Marton ;

Greff, Zoltan ;

Boros, Sandor ;

Banhegyi, Peter ;

Zsakai, Lilian ;

Szantai-Kis, Csaba ;

Vantus, Tibor ;

Mandl, Jazsef ;

Banhegyi, Gabor ;

Valyi-Nagy, Istvan ;

Orfi, Laszlo ;

Ullrich, Axel ;

Csala, Miklos ;

Keri, Gyorgy .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (02) :424-428

[2]

FSH stimulates IRS-2 expression in human granulosa cells through cAMP/SP1, an inoperative FSH action in PCOS patients [J].

Anjali, G. ;

Kaur, Surleen ;

Lakra, Ruchi ;

Taneja, Jyoti ;

Kalsey, Gaganjot S. ;

Nagendra, Anjali ;

Shrivastav, T. G. ;

Devi, M. Gouri ;

Malhotra, Neena ;

Kriplani, Alka ;

Singh, Rita .

CELLULAR SIGNALLING, 2015, 27 (12) :2452-2466

[3]

Melatonin inhibits tunicamycin-induced endoplasmic reticulum stress and insulin resistance in skeletal muscle cells [J].

Quan, Xiaojuan ;

Wang, Juyan ;

Liang, Chunlian ;

Zheng, Huadong ;

Zhang, Lin .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 463 (04) :1102-1107

[4]

Osteoblast Proliferation is Enhanced upon the Insulin Receptor Substrate 1 Overexpression via PI3K Signaling Leading to Down-regulation of NFκB and BAX Pathway.[J].H. Ma;JX. Ma;P. Xue;Y. Gao;YK. Li.Exp Clin Endocrinol Diabetes.2014,

[5]

Oleanolic acid supplement attenuates liquid fructose-induced adipose tissue insulin resistance through the insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt signaling pathway in rats [J].

Li, Ying ;

Wang, Jianwei ;

Gu, Tieguang ;

Yamahara, Johji ;

Li, Yuhao .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2014, 277 (02) :155-163

[6]

Induction of miR-29a by saturated fatty acids impairs insulin signaling and glucose uptake through translational repression of IRS-1 in myocytes [J].

Yang, Won-Mo ;

Jeong, Hyo-Jin ;

Park, Seung-Yoon ;

Lee, Wan .

FEBS LETTERS, 2014, 588 (13) :2170-2176

[7]

Downregulation of IRS-1 in adipose tissue of offspring of obese mice is programmed cell-autonomously through post-transcriptional mechanisms [J].

Fernandez-Twinn, Denise S. ;

Alfaradhi, Maria Z. ;

Martin-Gronert, Malgorzata S. ;

Duque-Guimaraes, Daniella E. ;

Piekarz, Ana ;

Ferland-McCollough, David ;

Bushell, Martin ;

Ozanne, Susan E. .

MOLECULAR METABOLISM, 2014, 3 (03) :325-333

[8]

Mapping the Structural Topology of IRS Family Cascades Through Computational Biology [J].

Chakraborty, Chiranjib ;

Doss, C. George Priya ;

Bandyopadhyay, Sanghamitra ;

Sarkar, Bimal Kumar ;

Haneef, S. A. Syed .

CELL BIOCHEMISTRY AND BIOPHYSICS, 2013, 67 (03) :1319-1331

[9]

Aspp2 negatively regulates body growth but not developmental timing by modulating IRS signaling in zebrafish embryos.[J].Chengdong Liu;Jing Luan;Yan Bai;Yun Li;Ling Lu;Yunzhang Liu;Fumihiko Hakuno;Shin-Ichiro Takahashi;Cunming Duan;Jianfeng Zhou.General and Comparative Endocrinology.2014,

[10]

α-Lipoic acid ameliorates impaired glucose uptake in LYRM1 overexpressing 3T3-L1 adipocytes through the IRS-1/Akt signaling pathway [J].

Qin, Zhen-Ying ;

Zhang, Min ;

Guo, Xi-Rong ;

Wang, Yu-Mei ;

Zhu, Guan-Zhong ;

Ni, Yu-Hui ;

Zhao, Ya-Ping ;

Qiu, Jie ;

Kou, Chun-Zhao ;

Qin, Rui ;

Cao, Xin-Guo .

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 2012, 44 (05) :579-586

← 1 2 →