Wnt、Notch信号在骨关节炎发病机制中的研究评述

被引：6

作者：

周静

宁乔怡

唐芳

王莹

徐晖

张琼予

周佳燕

马武开

机构：

[1] 贵阳中医学院第二附属院风湿免疫科

来源：

贵阳中医学院学报 | 2016年 / 38卷 / 01期

关键词：

骨关节炎; Wnt; Notch; β-catenin; 细胞信号; 综述;

D O I：

10.16588/j.cnki.issn1002-1108.2016.01.026

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

膝骨关节炎(KOA)的发病机制尚不完全清楚。本论文通过对国内外研究文献分析,探讨Wnt、Notch信号在OA骨细胞分化、增殖和凋亡,维持软骨细胞表型及基质代谢平衡方面发挥的重要作用,其信号通路异常可能是骨关节代谢失衡和KOA形成的关键因素。

引用

页码：84 / 87

页数：4

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