Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

被引：4647

作者：

MacDonald, Bryan T. ^{[1
]}

Tamai, Keiko ^{[2
]}

He, Xi ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, FM Kirby Neurobiol Ctr, Childrens Hosp Boston, Boston, MA 02115 USA

[2] Case Western Reserve Univ, Dept Genet, Cleveland, OH 44106 USA

来源：

DEVELOPMENTAL CELL | 2009年 / 17卷 / 01期

关键词：

RECEPTOR-RELATED PROTEIN-5; ADENOMATOUS POLYPOSIS-COLI; TERMINAL-BINDING-PROTEIN; SMALL-MOLECULE INHIBITOR; HIGH-AFFINITY LIGAND; BETA-CATENIN; CANONICAL WNT; COLORECTAL-CANCER; TRANSCRIPTIONAL ACTIVATION; PLASMA-MEMBRANE;

D O I：

10.1016/j.devcel.2009.06.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator beta-catenin controls embryonic development and adult homeostasis. Here we review recent progress in this so-called canonical Wnt signaling pathway. We discuss Wnt ligands, agonists, and antagonists, and their interactions with Wnt receptors. We also dissect critical events that regulate beta-catenin stability, from Wnt receptors to the cytoplasmic beta-catenin destruction complex, and nuclear machinery that mediates beta-catenin-dependent transcription. Finally, we highlight some key aspects of Wnt/beta-catenin signaling in human diseases including congenital malformations, cancer, and osteoporosis, and discuss potential therapeutic implications.

引用

页码：9 / 26

页数：18

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