支气管哮喘遗传学的研究进展与展望

被引：14

作者：

李飞

李为娟

高金明

机构：

[1] 中国医学科学院北京协和医学院北京协和医院呼吸内科

来源：

中华哮喘杂志(电子版) | 2010年 / 4卷 / 04期

关键词：

哮喘; 遗传学; 定位克隆; 候选基因; 全基因组关联研究;

D O I：

暂无

中图分类号：

R562.25 [];

学科分类号：

摘要：

遗传因素影响了支气管哮喘(简称哮喘)疾病及其相关表型的发生和发展。近年来随着高通量测序技术,单核苷酸多态性分型技术以及计算机数据处理能力的提高,哮喘遗传变异的识别能力已从单个候选基因的单一变异水平进展到识别许多基因的复杂变异水平。目前哮喘遗传学研究应综合考虑个体遗传易感性,基因-基因相互作用,基因-环境相互作用,以及表观遗传等多方面的影响。本文主要讨论哮喘遗传分析方法和技术上的进展,以及未来哮喘遗传学的发展。

引用

页码：282 / 287

页数：6

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