Allele-specific targeting of microRNAs to HLA-G and risk of asthma

被引：342

作者：

Tan, Zheng

Randall, Glenn

Fan, Jihua

Camoretti-Mercado, Blanca

Brockman-Schneider, Rebecca

Pan, Lin

Solway, Julian

Gern, James E.

Lemanske, Robert F., Jr.

Nicolae, Dan

Ober, Carole

机构：

[1] Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Microbiol, Chicago, IL 60637 USA

[3] Univ Chicago, Dept Med, Chicago, IL 60637 USA

[4] Univ Chicago, Dept Stat, Chicago, IL 60637 USA

[5] Univ Wisconsin, Dept Pediat, Madison, WI USA

[6] NYU, Sch Med, Skirball Inst Biomol Med, New York, NY USA

来源：

AMERICAN JOURNAL OF HUMAN GENETICS | 2007年 / 81卷 / 04期

关键词：

D O I：

10.1086/521200

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

HLA-G is a nonclassic, class I HLA molecule that has important immunomodulatory properties. Previously, we identified HLA-G as an asthma-susceptibility gene and discovered that the risk of asthma in a child was determined by both the child's HLA-G genotype and the mother's affection status. Here we report a SNP in the 3' untranslated region of HLA-G that influences the targeting of three microRNAs (miRNAs) to this gene, and we suggest that allele-specific targeting of these miRNAs accounts, at least in part, for our earlier observations on HLA-G and the risk of asthma.

引用

收藏

页码：829 / 834

页数：6

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