MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004)

被引：29849

作者：

Bartel, David P.

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

CELL | 2007年 / 131卷 / 04期

基金：

美国国家卫生研究院;

关键词：

DOUBLE-STRANDED-RNA; SHORT INTERFERING RNA; GERM-LINE DEVELOPMENT; SMALL TEMPORAL RNAS; C-ELEGANS; MESSENGER-RNA; CAENORHABDITIS-ELEGANS; NUCLEAR EXPORT; REGULATORY RNA; PAZ DOMAIN;

D O I：

10.1016/S0092-8674(04)00045-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) are endogenous similar to 22 nt RNAs that can play important regulatory roles in animals and plants by targeting mRNAs for cleavage or translational repression. Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.

引用

页码：11 / 29

页数：19

共 133 条

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