心脏型脂肪酸结合蛋白在急性心肌梗死早期诊断中的应用价值

被引：6

作者：

唐春平

刘燕荣

沈琴

袁亮

桂鸣

机构：

[1] 南京医科大学第一附属医院心脏科

来源：

实用临床医药杂志 | 2013年 / 17卷 / 21期

关键词：

心脏型脂肪酸结合蛋白; 急性心肌梗死; 敏感性; 特异性;

D O I：

暂无

中图分类号：

R542.22 [];

学科分类号：

摘要：

目的探讨心脏型脂肪酸结合蛋白(H-FABP)在急性心肌梗死(AMI)患者中的临床应用价值。方法对于48例疑为急性冠脉综合征(ACS)的患者入院即刻查心电图及传统心肌损伤标志物,包括肌红蛋白(MYO)、心脏型肌钙蛋白T(CTnT)、肌酸激酶同工酶(CKMB),同时采血分离血清行H-FABP定性测试。结果 H-FABP检测AMI的敏感性显著高于CKMB及cTnT,与MYO相似,其特异性与CTnT相似,略高于CKMB及MYO;H-FABP联合cTnT及CKMB诊断AMI的敏感性与MYO+CKMB+cTnT组合相同,但特异性略高于后者。4种心肌损伤标志物联合敏感性进一步提高,但特异性低于前述3项联合。对于症状出现3 h内就诊的患者,H-FABP检测AMI的敏感性与MYO无显著差异,但显著高于CKMB及cTnT;H-FABP检测AMI特异性与MYO、cTnT及CKMB无显著差异;在AMI早期诊断敏感性及特异性方面,三种组合方案均无显著差异。结论 H-FABP定性检测在AMI的早期诊断过程中具有明显高于CKMB及cTnT的敏感性,在急诊一线工作中值得推广。

引用

页码：8 / 11

页数：4

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