小儿生物可降解血管支架新型材料血液相容性评价(英文)

被引：2

作者：

赵丽娇

孙锟

冯其茂

王剑

机构：

[1] 上海交通大学医学院附属上海儿童医学中心

来源：

临床儿科杂志 | 2010年 / 28卷 / 09期

关键词：

生物可降解; 血管支架; 血液相容性; 体外;

D O I：

暂无

中图分类号：

R318.08 [生物材料学];

学科分类号：

100103 [病原生物学];

摘要：

目的评价以对二氧环己酮(PDO)为材料的生物可降解血管支架的血液相容性。方法通过体外动态凝血试验、凝血时间测定、血小板黏附试验、溶血率测定,在体外评价PDO可降解血管支架的血液相容性,并和目前已广泛应用于临床的316L不锈钢金属支架进行比较。结果 PDO可降解血管支架与316L不锈钢金属支架抗血液凝固性能相仿,二者对内源性及外源性凝血因子均无激活作用。与316L不锈钢金属支架相比,PDO可降解血管支架对血小板黏附和激活作用较轻。PDO可降解血管支架与316L不锈钢金属支架的溶血率均<5%。结论对二氧环己酮生物可降解血管支架有较好的血液相容性。

引用

页码：801 / 806

页数：6

共 8 条

[1]

Early- and Long-Term Intravascular Ultrasound and Angiographic Findings After Bioabsorbable Magnesium Stent Implantation in Human Coronary Arteries [J].

Waksman, Ron ;

Erbel, Raimund ;

Di Mario, Carlo ;

Bartunek, Jozef ;

de Bruyne, Bernard ;

Eberli, Franz R. ;

Erne, Paul ;

Haude, Michael ;

Horrigan, Mark ;

Ilsley, Charles ;

Boese, Dirk ;

Bonnier, Hans ;

Koolen, Jacques ;

Luescher, Thomas F. ;

Weissman, Neil J. .

JACC-CARDIOVASCULAR INTERVENTIONS, 2009, 2 (04) :312-320

[2]

Hemocompatibility and cytocompatibility of styrenesulfonate-grafted PDMS–polyurethane–HEMA hydrogel.[J].Chien-Hong Lin;Win-Chun Jao;Yi-Hsing Yeh;Wen-Ching Lin;Ming-Chien Yang.Colloids and Surfaces B: Biointerfaces.2009, 1

[3]

Promise and challenges of bioabsorbable stents [J].

Waksman, Ron .

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, 2007, 70 (03) :407-414

[4]

Early restenosis following biodegradable stent implantation in an aortopulmonary collateral of a patient with pulmonary atresia and hypoplastic pulmonary arteries [J].

McMahon, Colin J. ;

Oslizlok, Paul ;

Walsh, Kevin P. .

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, 2007, 69 (05) :735-738

[5]

Hemocompatibility evaluation of poly(glycerol-sebacate) in vitro for vascular tissue engineering.[J].Delara Motlagh;Jian Yang;Karen Y. Lui;Antonio R. Webb;Guillermo A. Ameer.Biomaterials.2006, 24

[6]

Corrosion resistance and hemocompatibility of multilayered Ti/TiN-coated surgical AISI 316L stainless steel.[J].Liu Chenglong;Yang Dazhi;Lin Guoqiang;Qi Min.Materials Letters.2005, 29

[7]

Blood-compatibility of polyurethane/liquid crystal composite membranes [J].

Zhou, CR ;

Yi, ZJ .

BIOMATERIALS, 1999, 20 (22) :2093-2099

[8]

Artificial heart valves:.[J].Feng Zhang;Xianghuai Liu;Yingjun Mao;Nan Huang;Yu Chen;Zhihong Zheng;Zuyao Zhou;Anqing Chen;Zhenbin Jiang.Surface & Coatings Technology.1998,

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